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Fig. 5 | BMC Endocrine Disorders

Fig. 5

From: Expression of T-cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domains (TIGIT) in anaplastic thyroid carcinoma

Fig. 5

TIGIT immunohistochemical results of composite type ATCs. In H&E-stained sections, ATC components showing pleomorphic/giant cell shape (left) were concomitantly seen with adjacent FTC components (right) (A). The FTC cells were completely negative for TIGIT, while ATC cells were starkly positive (B). In PTC-composite ATC, the PTC cells showed tall cell morphology with partial hobnail structures (H&E) (C). These neoplastic cells completely lacked immunoreactivity for TIGIT (D)

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