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Table 1 The clinical histories and characteristics of the GAD-positive patients (LADA) in comparison with the GAD-negative patients (T2D) (n = 156)

From: Prevalence and factors associated with latent autoimmune diabetes in adults (LADA): a cross-sectional study

Clinical histories and characteristics

Glutamate Decarboxylase status

 

Total

LADA

TYPE 2 DM

p-value

n = 8

n = 148

n (%)

n (%)

Sex

 Females

96 (61.5)

6 (75.0)

90 (60.8)

0.711

 Males

60 (38.5)

2 (25.0)

58 (39.2)

 Age (mean ± SD)

54.3 ± 11.7

55.8 ± 16.6

54.2 ± 11.5

0.135t

 BMI (mean ± SD)

27.5 ± 5.3)

28.5 ± 3.9

27.4 ± 5.4

0.309t

BMI distribution

 Underweight

7 (4.5)

0 (0)

7 (4.7)

1.00

 Normal

45 (28.9)

2 (25.0)

43 (29.1)

 

 Overweight/ Obese

104 (66.7)

6 (75.0)

98 (66.2)

 

Age onset of diabetes [median (IQR)]

52 (41- 62)

46.5 (38.3-68.5)

53 (41- 62)

0.698

Duration of diabetes in years [median (IQR)]

3 (1 – 4)

3.5(2.3-5)

3 (1 - 4)

0.803

History of alcohol

59 (37.8)

4 (50.0)

55 (37.2)

0.478

History of cigarettes

24 (15.4)

1 (12.5)

23 (15.5)

1.00

Family history with diabetes

72 (46.2)

3 (37.5)

69 (46.6)

0.726

Frequent urination

138 (88.5)

8 (100)

130 (87.8)

0.598

Ketonuria

16 (10.3)

2 (25.0)

14 (9.5)

0.192

Blurred vision

118 (75.6)

6 (75.0)

112 (75.7)

1.00

Increasing thirst

126 (80.8)

5 (62.5)

121 (81.8)

0.182

HIV positive (positive only)

24 (15.4)

1 (12.5)

23 (15.5)

1.00

MTB positive

12 (7.7)

0 (0)

12 (8.1)

1.00

Oral hypoglycaemia

139 (89.1)

8 (100)

131 (88.5)

0.60

Fasting blood sugar level at diagnosis (mean, SD)

21.8 (7.9)

23.3 (8.1)

21.8 (7.9)

0.948t

  1. LADA Latent autoimmune diabetes in adults, DM Diabetes mellitus, BMI Body mass index, SD Standard deviation, IQR Inter quaternary range, HIV Human immunodeficiency virus, MTB Mycobacterium tuberculosis.
  2. Note: Superscript t indicates p-values obtained from the t-test, other P-values obtained from Fisher’s Exact Test