Diagnostic accuracy of palpation versus ultrasound-guided fine needle aspiration biopsy for diagnosis of malignancy in thyroid nodules: a systematic review and meta-analysis

Tarigan, Tri Juli Edi; Anwar, Budiman Syaeful; Sinto, Robert; Wisnu, Wismandari

doi:10.1186/s12902-022-01085-5

Table 6 The results of diagnostic accuracy from each study

From: Diagnostic accuracy of palpation versus ultrasound-guided fine needle aspiration biopsy for diagnosis of malignancy in thyroid nodules: a systematic review and meta-analysis

Study (year)	Technique	Sample size	Diagnosis of cancer based on histopathology
Study (year)	Technique	Sample size	Sensitivity	Specificity	PPV	NPV	LR (+)	LR (−)	Accuracy
Takashima et al. (1994) [9]	PGFNAB	34	87.50	90.00	95.45	75.00	8.75	0.14	88.2
Takashima et al. (1994) [9]	USGFNAB	99	95.52	90.63	95.52	90.63	10.19	0.05	93.9
Hatada et al. (1998) [11]	PGFNAB	66	54.76	95.83	95.83	54.76	13.14	0.47	69.7
Hatada et al. (1998) [11]	USGFNAB	60	66.7	96.3	95.7	70.3	18.0	0.3	80.0
Danese et al. (1998) [10]	PGFNAB	522	91.9	68.8	36.7	97.7	2.9	0.1	72.6
Danese et al. (1998) [10]	USGFNAB	535	97.1	70.9	44.0	99.0	3.3	0.0	75.9
Carmeci et al. (1998) [12]	PGFNAB	41	89.5	50.0	60.7	84.6	1.8	0.2	68.3
Carmeci et al. (1998) [12]	USGFNAB	15	100.0	20.0	71.4	100.0	1.3	0.0	73.3
Solymosi et al. (2001) [23]	PGFNAB	317	76.0	65.4	15.8	97.0	2.2	0.4	66.2
Solymosi et al. (2001) [23]	USGFNAB	380	92.1	70.2	25.5	98.8	3.1	0.1	72.4
Goudy et al. (2005) [13]	PGFNAB	18	100.0	92.3	83.3	100.0	13.0	0.0	94.4
Goudy et al. (2005) [13]	USGFNAB	11	100.0	44.4	28.6	100.0	1.8	0.0	54.5
Cesur et al. (2006) [14]	PGFNAB	18	66.7	75.0	57.1	81.8	2.7	0.4	72.2
Cesur et al. (2006) [14]	USGFNAB	22	85.7	86.7	75.0	92.9	6.4	0.2	86.4
Izquierdo et al. (2006) [15]	PGFNAB	23	63.6	58.3	58.3	63.6	1.5	0.6	60.9
Izquierdo et al. (2006) [15]	USGFNAB	5	100.0	50.0	75.0	100.0	2.0	0.0	80.0
Can et al. (2008) [16]	PGFNAB	15	100.0	92.3	66.7	100.0	13.0	0.0	93.3
Can et al. (2008) [16]	USGFNAB	22	100.0	78.6	72.7	100.0	4.7	0.0	86.4
Krishnappa et al. (2013) [17]	PGFNAB	25	54.5	92.9	85.7	72.2	7.6	0.5	76.0
Krishnappa et al. (2013) [17]	USGFNAB	25	81.8	92.9	90.0	86.7	11.5	0.2	88.0
Guo et al. (2015) [18]	PGFNAB	99	93.4	95.7	98.6	81.5	21.5	0.1	93.9
Guo et al. (2015) [18]	USGFNAB	380	90.4	66.7	96.3	42.1	2.7	0.1	88.2
Sharma et al. (2017) [19]	PGFNAB	49	83.3	86.0	45.5	97.4	6.0	0.2	85.7
Sharma et al. (2017) [19]	USGFNAB	80	75.0	96.1	50.0	98.6	19.0	0.3	95.0
Choong et al. (2018) [7]	PGFNAB	355	86.2	100	100	97.38	0.0	0.14	97.7
Choong et al. (2018) [7]	USGFNAB	228	85.71	99.4	98.2	94.8	141	0.14	95.6
Taha et al. (2020) [5]	PGFNAB	570	52.3	94.3	73.1	87.0	9.2	0.5	84.7
Taha et al. (2020) [5]	USGFNAB	392	69.7	91.1	75.3	88.6	7.8	0.3	85.1

LR Likelihood ratio

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