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Table 3 Relationship between HDL-C and the incident diabetes in different models

From: Non-linear relationship between high-density lipoprotein cholesterol and incident diabetes mellitus: a secondary retrospective analysis based on a Japanese cohort study

Variable

Crude model (HR.,95% CI, P)

Model I

(HR,95% CI, P)

Model II

(HR,95% CI, P)

GAM

(HR,95% CI, P)

Total

 HDL-C

0.13 (0.09, 0.18) < 0.0001

0.34 (0.23, 0.50) < 0.0001

0.54 (0.35, 0.82) 0.0044

0.47 (0.30, 0.75) 0.0015

 HDL-C(quartile)

  Q1

ref

ref

ref

ref

  Q2

0.53 (0.42, 0.68) < 0.0001

0.68 (0.53, 0.87) 0.0023

0.83 (0.64, 1.07) 0.1575

0.82 (0.63, 1.06) 0.1343

  Q3

0.28 (0.20, 0.39) < 0.0001

0.44 (0.31, 0.63) < 0.0001

0.58 (0.41, 0.83) 0.0031

0.54 (0.37, 0.79) 0.0014

  Q4

0.23 (0.15, 0.34) < 0.0001

0.45 (0.30, 0.70) 0.0003

0.67 (0.43, 1.05) 0.0791

0.58 (0.36, 0.94) 0.0266

P for trend

 < 0.0001

 < 0.0001

0.0056

0.0018

Female

    

 HDL-C

0.14 (0.07, 0.28) < 0.0001

0.41 (0.20, 0.84) 0.0155

0.92 (0.41, 2.07) 0.8386

1.04 (0.44, 2.44) 0.9330

 HDL-C(quartile)

  Q1

ref

ref

ref

ref

  Q2

0.47 (0.27, 0.81) 0.0070

0.67 (0.39, 1.17) 0.1606

1.07 (0.58, 1.98) 0.8178

1.13 (0.61, 2.06) 0.7021

  Q3

0.21 (0.11, 0.38) < 0.0001

0.41 (0.22, 0.77) 0.0056

0.73 (0.36, 1.49) 0.3869

0.77 (0.38, 1.55) 0.4589

  Q4

0.17 (0.09, 0.32) < 0.0001

0.43 (0.22, 0.85) 0.0145

0.90 (0.41, 1.99) 0.8013

1.01 (0.45, 2.28) 0.9841

P for trend

 < 0.0001

0.0051

0.5208

0.6933

Male

 HDL-C

0.17 (0.11, 0.26) < 0.0001

0.32 (0.20, 0.51) < 0.0001

0.45 (0.27, 0.76) 0.0030

0.37 (0.21, 0.65) 0.0005

 HDL-C(quartile)

  Q1

ref

ref

ref

ref

  Q2

0.53 (0.40, 0.70) < 0.0001

0.66 (0.50, 0.87) 0.0035

0.79 (0.59, 1.06) 0.1097

0.76 (0.56, 1.02) 0.0713

  Q3

0.31 (0.20, 0.46) < 0.0001

0.46 (0.30, 0.70) 0.0003

0.57 (0.37, 0.89) 0.0131

0.51 (0.32, 0.82) 0.0052

  Q4

0.28 (0.16, 0.50) < 0.0001

0.50 (0.28, 0.92) 0.0248

0.63 (0.34, 1.17) 0.1411

0.45 (0.23, 0.88) 0.0200

P for trend

 < 0.0001

 < 0.0001

0.0080

0.0011

  1. Crude model: we did not adjust for other covariants
  2. Model I: we adjusted for age, ethanol consumption, smoking, regular exerciser, SBP, DBP, BMI, WC
  3. Model II: we adjusted for age, ethanol consumption, smoking, regular exerciser, SBP, DBP, BMI, WC, TC, TG, HbA1c, FPG
  4. GAM: All covariates listed in Table 1 were adjusted. However, continuous covariates were adjusted as nonlinearity
  5. CI Confidence interval, Ref Reference
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BMC Endocrine Disorders

ISSN: 1472-6823

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