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Table 2 Unadjusted and adjusted odds ratio (OR) analysis for the significantly altered metabolites associated with high-risk CVD, low-risk CVD, and diabetes mellitus

From: Circulating amino acids and acylcarnitines correlated with different CAC score ranges in diabetic postmenopausal women using LC–MS/MS based metabolomics approach

Metabolites

Diabetes/ controls

Diabetes + low risk CVD/ controls

OR (95% CI)

P-Value

P-Valuea

P-Valueb

OR (95% CI)

P-Value

P-Valuea

P-Valueb

Serine

1.021 (1.003–1.039)

0.025

0.026

0.000

1.026 (1.006–1.045)

0.009

0.009

0.000

C10:1

1.003 (0.999–1.007)

0.134

0.166

0.899

1.006 (1.001–1.01)

0.016

0.017

0.579

C14:1

0.979 (0.964–0.994)

0.007

0.006

0.000

0.989 (0.974–1.004)

0.147

0.151

0.000

C14:2

0.974 (0.958–0.991)

0.003

0.003

0.000

0.974 (0.955–0.993)

0.007

0.008

0.000

C16:1

0.940 (0.906–0.975)

0.001

0.001

0.859

0.969 (0.942–0.997)

0.031

0.041

0.999

C18

1.027 (1.003–1.051)

0.030

0.038

0.865

1.042 (1.011–1.074)

0.007

0.009

0.689

C18:1

0.986 (0.974–0.997)

0.017

0.011

0.788

0.994 (0.984–1.005)

0.271

0.478

0.988

C18:2OH

0.994 (0.989–0.998)

0.006

0.008

0.546

0.995 (0.99–0.999)

0.020

0.020

0.625

Metabolites

Diabetes + high risk CVD/ controls

Diabetes + high risk CVD/ diabetes

OR (95% CI)

P-Value

P-Valuea

P-Valueb

OR (95% CI)

P-Value

P-Valuea

P-Valueb

Serine

1.023 (1.005–1.041)

0.010

0.008

0.000

1.002 (0.989–1.015)

0.732

0.630

0.341

C10:1

1.004 (1.001–1.08)

0.037

0.027

0.879

1.001 (0.997–1.005)

0.579

0.372

0.578

C14:1

0.983 (0.97–0.997)

0.016

0.010

0.000

1.005 (0.99–1.019)

0.534

0.631

0.072

C14:2

0.980 (0.965–0.994)

0.006

0.005

0.000

1.005 (0.99–1.021)

0.509

0.610

0.532

C16:1

0.976 (0.956–0.997)

0.023

0.025

0.742

1.039 (1.003–1.076)

0.034

0.028

0.036

C18

1.032 (1.008–1.056)

0.008

0.009

0.988

1.005 (0.982–1.029)

0.683

0.560

0.830

C18:1

0.989 (0.979–0.999)

0.027

0.060

0.854

1.003 (0.991–1.016)

0.590

0.311

0.060

C18:2OH

0.998 (0.996–1.0)

0.083

0.081

0.889

1.005 (1.0–1.009)

0.043

0.072

0.122

  1. Results were shown as odds ratio (OR) and the corresponding 95% confidence intervals (CI)
  2. a Adjusted P-Value by age, BMI, and time of menopause
  3. b Adjusted P-Value by age, BMI, time of menopause, lipid profile, diabetes duration, and medications
  4. C10:1, Decenoylcarnitine; C14:1, Tetradecenoylcarnitine; C14:2, Tetradecadienoylcarnitine; C16:1, Hexadecenoylcarnitine; C18, Octadecanoylcarnitine; C18:1, Octadecenoylcarnitine; C18:2-OH, 3-OH-octadecadienoyl