Table 3 Comparisons of the data in patients with benign nodules, PTC or MTC
Variable | Total (n = 509) | Benign nodule (n = 264) | PTC (n = 189) | MTC (n = 56) | Statistical magnitude | P |
|---|---|---|---|---|---|---|
Age, Mean ± SD | 48.22 ± 12.31 | 50.08 ± 12.32 | 45.62 ± 11.94 | 48.21 ± 12.09 | F = 7.388 | < .001 |
Gender, n (%) | χ2 = 4.300 | 0.116 | ||||
Male | 154 (30.26) | 72 (27.27) | 59 (31.22) | 23 (41.07) | ||
Female | 355 (69.74) | 192 (72.73) | 130 (68.78) | 33 (58.93) | ||
Tumor biomarkers | ||||||
CEA, n (%) | χ2 = 122.238 | < .001 | ||||
Negative | 385 (75.64) | 194 (73.48) | 172 (91.01) | 19 (33.93) | ||
Positive | 37 (7.27) | 6 (2.27) | 4 (2.12) | 27 (48.21) | ||
Unknown | 87 (17.09) | 64 (24.24) | 13 (6.88) | 10 (17.86) | ||
CT, n (%) | χ2 = 152.534 | < .001 | ||||
Negative | 383 (75.25) | 192 (72.73) | 172 (91.01) | 19 (33.93) | ||
Positive | 32 (6.29) | 2 (0.76) | 1 (0.53) | 29 (51.79) | ||
Unknown | 94 (18.47) | 70 (26.52) | 16 (8.47) | 8 (14.29) | ||
Thyroid function | ||||||
TSH, n (%) | Fisher | 0.151 | ||||
Negative | 468 (91.94) | 247 (93.56) | 171 (90.48) | 50 (89.29) | ||
Positive | 32 (6.29) | 13 (4.92) | 16 (8.47) | 3 (5.36) | ||
Unknown | 9 (1.77) | 4 (1.52) | 2 (1.06) | 3 (5.36) | ||
TPOAb, n (%) | χ2 = 27.822 | < .001 | ||||
Negative | 443 (87.03) | 242 (91.67) | 158 (83.60) | 43 (76.79) | ||
Positive | 47 (9.23) | 11 (4.17) | 29 (15.34) | 7 (12.50) | ||
Unknown | 19 (3.73) | 11 (4.17) | 2 (1.06) | 6 (10.71) | ||
TGAb, n (%) | χ2 = 22.977 | < .001 | ||||
Negative | 453 (89.00) | 242 (91.67) | 165 (87.30) | 46 (82.14) | ||
Positive | 38 (7.47) | 11 (4.17) | 23 (12.17) | 4 (7.14) | ||
Unknown | 18 (3.54) | 11 (4.17) | 1 (0.53) | 6 (10.71) | ||
TRAb, n (%) | χ2 = 74.632 | < .001 | ||||
Negative | 3 (0.59) | 2 (0.76) | 1 (0.53) | 0 (0.00) | ||
Positive | 407 (79.96) | 199 (75.38) | 181 (95.77) | 27 (48.21) | ||
Unknown | 99 (19.45) | 63 (23.86) | 7 (3.70) | 29 (51.79) | ||
Thyroid nodule | ||||||
Maximum diameter of nodule, M (Q1, Q3) | 1.80 (0.80, 3.40) | 3.00 (1.70, 4.00) | 0.80 (0.60, 1.40) | 1.75 (0.90, 3.15) | Z = 5.137 | < .001 |
Composition, n (%) | - | < 0.001 | ||||
Cystic | 54 (10.61) | 54 (20.45) | 0 (0.00) | 0 (0.00) | ||
Spongy | 4 (0.79) | 4 (1.52) | 0 (0.00) | 0 (0.00) | ||
Solid Cystic | 72 (14.15) | 60 (22.73) | 3 (1.59) | 9 (16.07) | ||
Solid | 379 (74.46) | 146 (55.30) | 186 (98.41) | 47 (83.93) | ||
Echogenicity, n (%) | - | < 0.001 | ||||
Anechoic | 55 (10.81) | 55 (20.83) | 0 (0.00) | 0 (0.00) | ||
Hyperechoic | 86 (16.90) | 80 (30.30) | 4 (2.12) | 2 (3.57) | ||
Hypoechoic | 341 (66.99) | 125 (47.35) | 172 (91.01) | 44 (78.57) | ||
Markedly Hypoechoic | 27 (5.30) | 4 (1.52) | 13 (6.88) | 10 (17.86) | ||
Shape, n (%) | χ2 = 22.950 | < 0.001 | ||||
A/T < 1 | 383 (75.25) | 241 (91.29) | 94 (49.74) | 48 (85.71) | ||
A/T ≥ 1 | 126 (24.75) | 23 (8.71) | 95 (50.26) | 8 (14.29) | ||
Margin, n (%) | χ2 = 7.555 | < 0.001 | ||||
Smooth or unclear | 367 (72.10) | 247 (93.56) | 87 (46.03) | 33 (58.93) | ||
Irregular or lobulated | 107 (21.02) | 17 (6.44) | 78 (41.27) | 12 (21.43) | ||
Extra thyroid extension | 35 (6.88) | 0 (0.00) | 24 (12.70) | 11 (19.64) | ||
Calcification, n (%) | - | < 0.001 | ||||
None | 270 (53.05) | 193 (73.11) | 59 (31.22) | 18 (32.14) | ||
Coarse calcifications | 47 (9.23) | 34 (12.88) | 11 (5.82) | 2 (3.57) | ||
Rim calcifications | 12 (2.36) | 4 (1.52) | 7 (3.70) | 1 (1.79) | ||
Micro calcifications | 180 (35.36) | 33 (12.50) | 59 (31.22) | 18 (32.14) | ||
Metastatic lymph nodes, n (%) | χ2 = 5.825 | < 0.001 | ||||
No | 451 (88.61) | 264 (100.00) | 151 (79.89) | 36 (64.29) | ||
Yes | 58 (11.39) | 0 (0.00) | 38 (20.11) | 20 (35.71) | ||