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Table 4 Multiple factors logistic regression analysis of thyroid hormones and risk of NAFLD and progressive liver fibrosis

From: Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function

 

Thyroid hormones and the risk of NAFLD

Thyroid hormones and the risk of progressive liver fibrosis

when NFS < 0.676, FT4 and the risk of NAFLD

OR

95%CI

p value

OR

95%CI

p value

OR

95%CI

p value

FT3

 Model 1

1.489

1.059–2.094

0.022*

0.532

0.334–0.846

0.008**

   

 Model 2

1.456

1.029–2.058

0.034*

0.56

0.35–0.899

0.016*

   

 Model 3

1.041

0.7–1.549

0.842

      

 Model 4

   

0.654

0.363–1.176

0.156

   

FT4

 Model 1

0.86

0.77–0.96

0.007**

0.798

0.679–0.937

0.006**

0.859

0.761–0.969

0.014*

 Model 2

0.857

0.767–0.957

0.006**

0.802

0.683–0.942

0.007**

   

 Model 3

0.865

0.762–0.982

0.026*

      

 Model 4

   

0.796

0.655–0.967

0.022*

   

 Model 5

      

0.856

0.758–0.968

0.013*

 Model 6

      

0.801

0.672–0.955

0.013*

TT3

 Model 1

2.171

1.025–4.602

0.043*

0.142

0.047–0.431

0.001***

   

 Model 2

2.095

0.985–4.457

0.055

0.152

0.05–0.464

0.001***

   

 Model 3

1.166

0.495–2.726

0.726

      

 Model 4

   

0.151

0.038–0.597

0.007**

   

TT4

 Model 1

   

0.985

0.97–1.0

0.047*

   

 Model 2

   

0.984

0.969–0.999

0.033*

   

 Model 4

   

0.98

0.962–1.0

0.046*

   

TSH

 Model 1

   

1.252

1.016–1.544

0.035*

   

 Model 2

   

1.224

0.99–1.513

0.062

   

 Model 4

   

1.13

0.884–1.446

0.33

   

FT3/FT4

 Model 1

2870.6

59.9–137,433.9

0.000***

   

2023.8

27.3–150,045.9

0.001***

 Model 2

2493.8

50.9–122,059.1

0.000***

      

 Model 3

99.0

1.3–7567.3

0.038*

      

 Model 5

      

1395.9

17.9–108,303.0

0.001***

 Model 6

      

7545.9

18.4–3,093,672.6

0.004***

  1. Annotation: Model 1 did not correct any factors. Model 2 corrected gender factor. Model 3 corrected gender, age, diastolic pressure, waistline, diabetes course, body mass index, triglyceride, high density lipoprotein, lipoprotein-A1 and lipoprotein-B factors. Model 4 corrected gender, age, diastolic pressure, waistline, diabetes course, and body mass index, total cholesterol and lipoprotein-B factors. Model 5corrected gender and age factors. Model 6 corrected gender, age, TT3, TT4, TSH factors
  2. NAFLD nonalcoholic fatty liver disease, NFS NAFLD fibrosis score, FT3 free triiodothyronine, FT4 free thyroxine, TT3 total triiodomethylamine, TT4 total thyroxine, TSH thyroid stimulating hormone
  3. *p < 0.05
  4. **p < 0.01
  5. ***p < 0.005