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Table 2 Comparison of the clinical data and thyroid hormone levels in T2DM patients with or without progressive liver fibrosis

From: Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function

 

T2DM with progressive liver fibrosis

T2DM without progressive liver fibrosis

p value

NFS > 0.676(n = 93)

NFS < 0.676(n = 493)

Sex (male/female)

34/59

229/264

0.079

Age (years)

71(66–78)

57(52–65)

0.000

Diabetes course (years)

10(6–19.5)

7(3–12)

0.000

Duration of treatment (years)

10(5–18.5)

6(1.75–12)

0.000

BMI (kg/m2)

26.79 ± 3.87

24.96 ± 3.36

0.000

Systolic pressure(mmHg)

135(124–149)

132(122–144.5)

0.214

Diastolic pressure(mmHg)

78(70.5–84)

82(76–90)

0.000

Waistline(cm)

96.04 ± 12.13

91.12 ± 9.79

0.000

Hipline (cm)

102(96–106.5)

99(94–103)

0.001

Waist hip ratio (WHR)

0.94(0.90–0.98)

0.92(0.89–0.96)

0.026

ALT(U/L)

15(11–20)

19(14–28)

0.000

AST(U/L)

17(15–20)

17(14–21)

0.575

AST/ALT

1.13(0.98–1.35)

0.86(0.70–1.07)

0.000

γ- GGT (U/L)

18(14–27.5)

24(17–34)

0.001

AKP(U/L)

90.0(73.0–110.5)

92.0(75.0–113.0)

0.477

FBG (mmol/L)

6.99(5.59–8.85)

7.70(6.22–10.23)

0.007

TG (mmol/L)

1.38(0.97–1.89)

1.50(1.02–2.24)

0.087

TC (mmol/L)

4.31 ± 1.08

4.64 ± 0.96

0.003

HDL (mmol/L)

1.15(0.94–1.37)

1.12(0.94–1.37)

0.971

LDL (mmol/L)

2.41(2.03–3.14)

2.80(2.24–3.36)

0.003

APO-A1(g/L)

1.26 ± 0.26

1.28 ± 0.25

0.451

APO-B(g/L)

0.85 ± 0.26

0.92 ± 0.22

0.003

FT3(pmol/L)

3.88 ± 0.53

4.03 ± 0.48

0.007

FT4(pmol/L)

12.79 ± 1.50

13.26 ± 1.50

0.006

TT3(nmol/L)

1.33(1.16–1.43)

1.39(1.25–1.55)

0.001

TT4(nmol/L)

83.36 ± 12.57

86.93 ± 16.34

0.018

FT3/FT4

0.306 ± 0.050

.307 ± 0.044

0.958

TSH (uIU/L)

2.2219(1.6204–3.2512)

2.0229(1.3759–2.8217)

0.028

HOMA-IR (CP)

3.1409(2.4986–3.8983)

3.2306(2.5629–3.9423)

0.441

FCP (ng/mL)

1.82(1.28–2.59)

1.79(1.17–2.58)

0.650

HbA1C (%)

7.60(6.80–8.85)

8.00(6.80–9.90)

0.173

FLI

40.30(19.81–61.26)

45.65(26.82–66.58)

0.090

  1. The measured data of the normal distribution was represented by mean ± SD. Measurement data for non-normal distributions were expressed as medians (interquartile intervals) *p < 0.05, **p < 0.01, ***p < 0.005 T2DM with NFS > 0.676 vs T2DM without NFS > 0.676
  2. T2DM Type 2 diabetes mellitus, BMI Body mass index, NFS Nonalcoholic fatty liver disease fibrosis score, ALT Alanine aminotransferase, AST Aspartic acid aminotransferase, GGT Glutamyltransferase, AKP Alkaline phosphatase, FBG Fasting blood glucose, TG Triglyceride, TC Total cholesterol, HDL High density lipoprotein, LDL Low density lipoprotein, APO-A1 Lipoprotein-A1, APO-B Lipoprotein-B, FT3 Free triiodothyronine, FT4 Free thyroxine, TT3 Total triiodomethylamine, TT4 Total thyroxine, TSH Thyroid stimulating hormone, Homa-IR (CP) Homa-Insulin resistance(C-peptide), FCP Fasting C-peptide, HbA1c Glycosylatedhemoglobin, FLI Fatty Liver-index. Abbreviations for other Tables are same