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Table 1 Comparison of clinical data and thyroid hormone levels in T2DM patients with or without NAFLD

From: Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function

 

T2DM without NAFLD (n = 240)

T2DM with NAFLD (n = 346)

P value

Sex (male/female)

101/139

162/184

0.257

Age (years)

62(54–70)

58.5(52–66)

0.002

Diabetes course (years)

10(5–14.75)

7(3–12)

0.004

Duration of treatment (years)

9(3–14)

7(1–12)

0.013

BMI (kg/m2)

23.81 ± 3.20

26.25 ± 3.37

0.000

Systolic pressure(mmHg)

132(122–142)

133(124–148)

0.280

Diastolic pressure(mmHg)

80(74–86)

82(76–90)

0.001

Waistline(cm)

88.22 ± 10.51

94.46 ± 9.43

0.000

Hipline (cm)

97(92–102)

101(96–105)

0.000

Waist hip ratio (WHR)

0.91(0.87–0.96)

0.93(0.90–0.97)

0.000

NFS

− 0.2479 ± 1.0663

−0.4283 ± 1.0132

0.038

ALT(U/L)

16(12–21)

20(15–30)

0.000

AST(U/L)

16(14–19)

17(15–22)

0.000

AST/ALT

1.00(0.82–1.25)

0.85(0.68–1.01)

0.000

γ- GGT (U/L)

18(14–26)

26(19–39)

0.000

AKP(U/L)

91.00(74.00–113.00)

92.00(75.75–114.00)

0.291

FBG (mmol/L)

7.11(5.75–10.41)

7.70(6.42–9.86)

0.032

TG (mmol/L)

1.16(0.84–1.64)

1.70(1.26–2.50)

0.000

TC (mmol/L)

4.51 ± 0.99

4.64 ± 0.98

0.107

HDL (mmol/L)

1.19(1.01–1.48)

1.07(0.92–1.31)

0.000

LDL (mmol/L)

2.65(2.10–3.32)

2.78(2.22–3.32)

0.276

APO-A1(g/L)

1.30 ± 0.25

1.25 ± 0.25

0.025

APO-B(g/L)

0.87 ± 0.23

0.94 ± 0.22

0.000

FT3(pmol/L)

3.95 ± 0.51

4.04 ± 0.47

0.021

FT4(pmol/L)

13.39 ± 1.53

13.04 ± 1.49

0.007

TT3(nmol/L)

1.35(1.21–1.52)

1.39(1.26–1.55)

0.032

TT4(nmol/L)

87.11 ± 15.96

85.84 ± 15.77

0.341

FT3/FT4

0.297 ± 0.044

.313 ± 0.045

0.000

TSH (uIU/L)

2.0201(1.4275–2.9372)

2.0534(1.3637–2.8333)

0.708

HOMA-IR (CP)

2.8429(2.2891–3.4687)

3.4185(2.7337–4.3036)

0.000

FCP (ng/mL)

1.47(0.99–2.03)

2.15(1.43–2.77)

0.000

HBA1C (%)

7.70(6.73–9.90)

8.00(6.80–9.63)

0.503

FLI

23.31(10.51–41.11)

53.35(34.53–71.37)

0.000

  1. The measured data of the normal distribution was represented by mean ± SD. Measurement data for non-normal distributions were expressed as medians (interquartile intervals) *p < 0.05, **p < 0.01, ***p < 0.005 T2DM with NAFLD vs T2DM without NAFLD
  2. NAFLD Nonalcoholic fatty liver disease, T2DM Type 2 diabetes mellitus, BMI Body mass index, NFS NAFLD fibrosis score, ALT Alanine aminotransferase, AST Aspartic acid aminotransferase, GGT Glutamyltransferase, AKP Alkaline phosphatase, FBG Fasting blood glucose, TG Triglyceride, TC Total cholesterol, HDL High density lipoprotein, LDL Low density lipoprotein, APO-A1 Lipoprotein-A1, APO-B Lipoprotein-B, FT3 Free triiodothyronine, FT4 Free thyroxine, TT3 Total triiodomethylamine, TT4 Total thyroxine, TSH Thyroid stimulating hormone, Homa-IR (CP) Homa-Insulin resistance(C-peptide), FCP Fasting C-peptide, HbA1c Glycosylatedhemoglobin, FLI Fatty Liver-index. Abbreviations for other Tables are same