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Table 5 Association between type 2 diabetes status and prevalence of significant fibrosis

From: Association between type 2 diabetes status and prevalence of liver steatosis and fibrosis among adults aged ≥ 40 years

 

Model 1 OR (95% CI, P)

Model 2 OR (95% CI, P)

Model 3 OR (95% CI, P)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

3.3 (2.6, 4.1) < 0.001

3.3 (2.6, 4.2) < 0.001

2.0 (1.5, 2.7) < 0.001

Stratified by sex

Men (n = 1,328)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

2.9 (2.2, 4.0) < 0.001

3.1 (2.3, 4.3) < 0.001

1.8 (1.2, 2.8) 0.004

Women (n = 1,452)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

3.6 (2.6, 5.0) < 0.001

3.6 (2.5, 5.0) < 0.001

2.0 (1.3, 3.1) 0.003

Stratified by age

40–59 age group (n = 1,240)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

4.6 (3.2, 6.6) < 0.001

4.5 (3.1, 6.5) < 0.001

2.3 (1.4, 3.9) 0.002

60–80 age group (n = 1,540)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

2.7 (2.1, 3.7) < 0.001

2.7 (2.0, 3.7) < 0.001

2.0 (1.4, 2.9) < 0.001

Stratified by race

Non-Hispanic White (n = 979)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

3.5 (2.4, 5.2) < 0.001

3.5 (2.4, 5.3) < 0.001

2.0 (1.2, 3.4) 0.011

Non-Hispanic Black (n = 624)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

1.9 (1.2, 2.9) 0.008

1.9 (1.2, 3.0) 0.006

1.7 (1.0, 3.1) 0.067

Mexican American (n = 362)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

3.0 (1.7, 5.3) < 0.001

3.0 (1.6, 5.5) < 0.001

1.6 (0.7, 3.7) 0.228

Other race (n = 815)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

5.5 (3.5, 8.6) < 0.001

5.5 (3.4, 8.8) < 0.001

2.9 (1.5, 5.5) 0.001

Stratified by body mass index (BMI)

BMI < 25 (kg/m2) (n = 632)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

2.4 (1.2, 4.7) 0.013

2.3 (1.1, 4.8) 0.021

3.3 (1.3, 8.8) 0.015

BMI ≥ 25, < 30 (kg/m2) (n = 951)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

2.7 (1.6, 4.4) < 0.001

2.2 (1.3, 3.8) 0.003

1.5 (0.7, 3.1) 0.257

BMI ≥ 30 (kg/m2) (n = 1,197)

Non- diabetes

Reference

Reference

Reference

Type 2 diabetes

2.9 (2.2, 3.8) < 0.001

2.9 (2.2, 3.9) < 0.001

2.3 (1.6, 3.3) < 0.001

  1. Model 1: no covariates were adjusted
  2. Model 2: age, sex, race were adjusted
  3. Model 3: age, sex, race, educational level, body mass index, ratio of family income to poverty, moderate recreational activities, smoked at least 100 cigarettes in life, blood urea nitrogen, total cholesterol, serum uric acid, alkaline phosphatase, alanine amino transferase, aspartic acid transferase, Gamma-glutamyl transpeptidase, and serum glucose were adjusted
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BMC Endocrine Disorders

ISSN: 1472-6823

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