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Table 4 Odds ratios (95% confidence interval) for diabetes by the level of liver enzymes within normal range

From: Serum liver enzymes and diabetes from the Rafsanjan cohort study

Characteristics

Crude model

Adjusted model 1

Adjusted model 2

Adjusted model 3

Adjusted model 4

OR (95%CI)a

OR(95%CI)b

OR (95%CI)c

OR(95%CI)d

OR(95%CI)e

ALT

 Normal Quartile 1

1

1

1

1

1

 Normal Quartile 2

1.36(1.17–1.58)

1.36(1.16–1.60)

1.25(1.07–1.48)

1.26(1.06–1.49)

1.19(1.01–1.42)

 Normal Quartile 3

1.90(1.65–2.18)

1.83(1.58–2.13)

1.64(1.40–1.91)

1.61(1.37–1.89)

1.42(1.20–1.67)

 Normal Quartile 4

2.04(1.78–2.35)

2.25(1.93–2.61)

1.94(1.66–2.26)

1.88(1.60–2.21)

1.61(1.37–1.90)

 Elevated ALT

2.19(1.83–2.62)

3.37(2.78–4.09)

2.86(2.34–3.50)

2.82(2.29–3.46)

2.40(1.94–2.97)

AST

 Normal Quartile 1

1

1

1

1

1

 Normal Quartile 2

0.68(0.59–0.78)

0.62(0.54–0.72)

0.61(0.52–0.71)

0.61(0.52–0.71)

0.59(0.50–0.70)

 Normal Quartile 3

0.81(0.71–0.91)

0.68(0.59–0.78)

0.66(0.57–0.76)

0.67(0.58–0.77)

0.63(0.54–0.73)

 Normal Quartile 4

0.88(0.77–1.00)

0.82(0.71–0.94)

0.56(0.66–0.87)

0.75(0.65–0.87)

0.69(0.59–0.80)

 Elevated AST

1.49(1.15–1.92)

1.51(1.14–2.00)

1.36(1.03–1.81)

1.36(1.02–1.82)

1.28(0.95–1.71)

GGT

 Normal Quartile 1

1

1

1

1

1

 Normal Quartile 2

1.92(1.63–2.26)

1.79(1.51–2.12)

1.63(1.37–1.94)

1.61(1.35–1.93)

1.50(1.25–1.80)

 Normal Quartile 3

2.40(2.04–2.81)

2.27(1.92–2.69)

1.98(1.67–2.35)

1.96(1.64–2.33)

1.75(1.46–2.10)

 Normal Quartile 4

3.57(3.07–4.17)

3.63(3.08–4.27)

3.11(2.63–3.67)

2.99(2.52–3.55)

2.60(2.17–3.11)

 Elevated GGT

4.63(3.89–5.53)

4.34(3.60–5.25)

3.72(3.06–4.50)

3.68(3.01–4.48)

3.10(2.51–3.82)

ALP

 Normal Quartile 1

1

1

1

1

1

 Normal Quartile 2

1.17(1.01–1.37)

1.03(0.88–1.22)

0.99(0.85–1.17)

1.01(0.85–1.19)

0.98(0.83–1.17)

 Normal Quartile 3

1.49(1.28–1.73)

1.20(1.02–1.41)

1.11(0.94–1.30)

1.13(0.96–1.33)

1.09(0.92–1.29)

 Normal Quartile 4

1.97(1.71–2.28)

1.50(1.28–1.74)

1.40(1.20–1.64)

1.39(1.19–1.63)

1.30(1.10–1.54)

 Elevated ALP

2.78(2.34–3.30)

1.96(1.63–2.36)

1.88(1.56–2.27)

1.90(1.56–2.31)

1.76(1.44–2.16)

  1. a The baseline model is stratified on the levels of liver enzymes
  2. b The adjusted model 1 is adjusted for confounding variables including age (continuous variable), gender (male/ female), education years (continuous variable) and wealth status index
  3. C The adjusted model 2 has additional adjustment for confounding variables related to lifestyle (cigarette smoking, alcohol drinking and opium consumption), body mass index (continuous variable) and physical activity level (continuous variable)
  4. d The adjusted model 3 has additional adjustment for hypertension (yes/no), family history of diabetes (first-degree relatives) (yes/no) and family history of diabetes (second-degree relatives) (yes/no)
  5. e The adjusted model 4 has additional adjustment for cholesterol (continuous variable), triglycerides (continuous variable), LDL cholesterol (continuous variable), HDL cholesterol (continuous variable), use of hepatotoxic drugs (yes/no) and fatty liver (yes/no)