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Table 1 Genotype distribution and allele frequencies of OCT-1 polymorphisms in responders and non-responders

From: Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes

Genotype Responder (n = 25) Non-responder (n = 16) P-value
OCT-1 (156 T > C)
 TT 15 (60.0%) 9 (56.0%)  > 0.05
 TC 10 (40.0%) 7 (44.0%)  
Alleles
 T 40 (80%) 25 (78.125%)  > 0.05
 C 10 (20%) 7 (21.875%)  
OCT-1 (181 C > T)
 CC 25 (100%) 6 (37.5%)  < 0.001
 CT 0 10 (62.5%)  
Alleles
 C 50 (100%) 22 (68.75%)  < 0.001
 T 0 (0%) 10 (31.25%)  
OCT-1 (1201 G > A)
 GG 25 (100%) 12(75.0%)  < 0.05
 GA 0 4 (25%)  
Alleles
 G 50 (100%) 28 (87.5%)  < 0.05
 A 0 (0%) 4 (12.5%)  
OCT-1 (1222A > G)
 AA 0 2 (12.5%)  < 0.05
 AG 05 (20.0%) 9 (56.25%)  
 GG 20 (80.0%) 5 (31.25%)  
Alleles
 A 5 (10%) 13 (40.625%)  < 0.05
 G 45 (90%) 19 (59.375%)