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Fig. 5 | BMC Endocrine Disorders

Fig. 5

From: Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes

Fig. 5

a Effect of A769962 on AMPK phosphorylation in mock, reference OCT-1 and mutant transfects: Representative ummunoblots showing the change in pAMPK expression by the presence/absence of A769962 in HepG2 cells expressing vehicle control, reference OCT-1 and mutant OCT-1 constructs. The lower panel represents the effect of the same on the expression of β–actin protein used as a loading control. M1: 181C > T; M2; 1201G > A; M3: 1222A > G. b Graph showing normalised densitometric values for the A769962 treated and untreated mock, wild type cells and mutant cells

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