Use of thyroid hormones in hypothyroid and euthyroid patients: a 2020 THESIS questionnaire survey of members of the Czech Society of Endocrinology

Table 3 Multiple regression model of the predictors of reasons for persistent hypothyroid symptoms despite normal serum TSH

		Independent variables
		Sex 1-Female 0-Male	Age group	Years in medical practice	Thyroid hormones may be indicated in biochemically euthyroid patients with…*
Dependent variables	Inability of levothyroxine to restore normal physiology	NS	NS	NS	NS
	Psychosocial factors	NS	β-coeff. = -0.278 Std. Error = 0.128 P = 0.031	NS	NS
	Comorbidities	β-coeff. = 0.312 Std. Error = 0.129 P = 0.017	NS	NS	NS
	Chronic fatigue syndrome	β-coeff. = 0.353 Std. Error = 0.165 P = 0.033	NS	NS	NS
	Patient unrealistic expectation	β-coeff. = 0.319 Std. Error = 0.160 P = 0.048	β-coeff. = -0.355 Std. Error = 0.138 P = 0.011	β-coeff. = 0.383 Std. Error = 0.138 P = 0.006	NS
	Presence of underlying inflammation due to autoimmunity	NS	NS	NS	NS
	The burden of chronic disease	NS	NS	NS	NS

^* …depression resistant to anti-depressant medications; female infertility with high level of thyroid antibodies; simple goitre growing over time; unexplained fatigue; obesity resistant to life-style interventions; severe hypercholesterolemia, as a complementary treatment (sum of all “Yes” answers in each respondent)
TSH Thyroid stimulating hormone, NS Not significant, P Level of significance

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