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Table 3 Multiple regression model of the predictors of reasons for persistent hypothyroid symptoms despite normal serum TSH

From: Use of thyroid hormones in hypothyroid and euthyroid patients: a 2020 THESIS questionnaire survey of members of the Czech Society of Endocrinology

  Independent variables
Sex
1-Female
0-Male
Age group Years in medical practice Thyroid hormones may be indicated in biochemically euthyroid patients with…*
Dependent variables Inability of levothyroxine to restore normal physiology NS NS NS NS
Psychosocial factors NS β-coeff. = -0.278
Std. Error = 0.128
P = 0.031
NS NS
Comorbidities β-coeff. = 0.312
Std. Error = 0.129
P = 0.017
NS NS NS
Chronic fatigue syndrome β-coeff. = 0.353
Std. Error = 0.165
P = 0.033
NS NS NS
Patient unrealistic expectation β-coeff. = 0.319
Std. Error = 0.160
P = 0.048
β-coeff. = -0.355
Std. Error = 0.138
P = 0.011
β-coeff. = 0.383
Std. Error = 0.138
P = 0.006
NS
Presence of underlying inflammation due to autoimmunity NS NS NS NS
The burden of chronic disease NS NS NS NS
  1. * …depression resistant to anti-depressant medications; female infertility with high level of thyroid antibodies; simple goitre growing over time; unexplained fatigue; obesity resistant to life-style interventions; severe hypercholesterolemia, as a complementary treatment (sum of all “Yes” answers in each respondent)
  2. TSH Thyroid stimulating hormone, NS Not significant, P Level of significance