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Table5 Demographics, gland involvement, treatment, and genetic features of MEN1 patients with macronodular hyperplasia (current case)

From: Long delay in diagnosis of a case with MEN1 due to concomitant presence of AIMAH with insulinoma: a case report and literature review

Author, [reference]

year

Gender

Parathyroid lesion(pos/neg)

Pituitary

Lesion (pos/neg)

Pancreas

Lesion (pos/neg)

Treatment

Mutation

Burgess [16]

1996

2 patients, 1 female and 1 male

Positive for both

Negative for 1, not described for the other

Positive for both, gastrinoma for 1, not described for the other

Right adrenalectomy for 1, the other patient died

Not performed

Barzon [17]

2001

2 patients, not described

Not clearly identified

Not clearly identified

Not clearly identified

Not clearly identified

Not clearly identified

Langer [18]

2002

2 patients, both female

Not described

Not described

Not described

Bilateral adrenalectomy for both patients

E191X for 1 patient, splice-site for the other patient

Waldmann [19]

2007

1 patient, female

Not described

Not described

Not described

Left adrenalectomy

L168P Ex 3

Sato [15]

2006

1 patient, female

positive

negative

negative

Left adrenalectomy

Not performed

Hsiao [13]

2009

1 patient, Male

positive

negative

negative

Not described

Pro494Leu

Lee [14]

2011

1 patient, female

negative

negative

Positive, insulinoma

Bilateral adrenalectomy, pancreas lesion was removed

Not performed

Yoshida [12]

2011

1 patient, male

positive

positive

Positive, insulinoma

Right adrenalectomy, spleen-preserving pancreatectomy

No mutation

Current case

2021

1 patient, female

positive

positive

Positive, insulinoma

left adrenalectomy, spleen-preserving distal pancreatectomy

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