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Table5 Demographics, gland involvement, treatment, and genetic features of MEN1 patients with macronodular hyperplasia (current case)

From: Long delay in diagnosis of a case with MEN1 due to concomitant presence of AIMAH with insulinoma: a case report and literature review

Author, [reference] year Gender Parathyroid lesion(pos/neg) Pituitary
Lesion (pos/neg)
Pancreas
Lesion (pos/neg)
Treatment Mutation
Burgess [16] 1996 2 patients, 1 female and 1 male Positive for both Negative for 1, not described for the other Positive for both, gastrinoma for 1, not described for the other Right adrenalectomy for 1, the other patient died Not performed
Barzon [17] 2001 2 patients, not described Not clearly identified Not clearly identified Not clearly identified Not clearly identified Not clearly identified
Langer [18] 2002 2 patients, both female Not described Not described Not described Bilateral adrenalectomy for both patients E191X for 1 patient, splice-site for the other patient
Waldmann [19] 2007 1 patient, female Not described Not described Not described Left adrenalectomy L168P Ex 3
Sato [15] 2006 1 patient, female positive negative negative Left adrenalectomy Not performed
Hsiao [13] 2009 1 patient, Male positive negative negative Not described Pro494Leu
Lee [14] 2011 1 patient, female negative negative Positive, insulinoma Bilateral adrenalectomy, pancreas lesion was removed Not performed
Yoshida [12] 2011 1 patient, male positive positive Positive, insulinoma Right adrenalectomy, spleen-preserving pancreatectomy No mutation
Current case 2021 1 patient, female positive positive Positive, insulinoma left adrenalectomy, spleen-preserving distal pancreatectomy 11e85Serfs Ter33