Table 3 Associations of SNPs with BMI in three genetic models
SNP | Genetic Model | Genotype | Non-obese | Obese | Crude | Model 1 | Model 2 |
|---|---|---|---|---|---|---|---|
(n = 156) | (n = 164) | OR (CI- 95%) (P.value) | OR (CI- 95%) (P.value) | OR (CI- 95%) (P.value) | |||
bsm.rs1 SNP | Additive | GG | 89 (57.1) | 88 (53/8) | 1(references) | 1(references) | 1(references) |
GT | 53 (34) | 63 (38.4) | 1.04 (0.75-1.92) | 1.21 (0.76-1.97) | 1.13 (0.68-1.87) | ||
p = 0.44 | p = 0.41 | p = 0.62 | |||||
TT | 14 (9) | 13 (7.9) | 0.93 (0.41-2.12) | 0.95 (0.41-2.17) | 0.94 (0.39-2.25) | ||
p = 0.87 | p = 0.90 | p = 0.89 | |||||
Dominant | GG | 89 (57.1) | 88 (53.7) | 1(references) | 1(references) | 1(references) | |
GT/TT | 67 (42.9) | 76 (46.3) | 1.14 (0.73-1.78) | 1.16 (0.74-1.82) | 1.09 (0.68-1.75) | ||
p = 0.94 | p = 0.51 | p = 0.70 | |||||
Recessive | GT/GG | 142 (91) | 151 (92.1) | 1(references) | 1(references) | 1(references) | |
TT | 14 (9) | 13 (7.9) | 0.87 (0.39-1.92) | 0.87 (0.39-1.97) | 0.89 (0.38-2.09) | ||
p = 0.73 | p = 0.74 | p = 0.79 | |||||
Alleles | G | 231 (74.1) | 239 (72.8) | – | – | – | |
T | 75 (25.7) | 78 (26) | – | – | – | ||
Mspl.rs2 SNP | Additive | GG | 134 (85.9) | 146 (89) | 1(references) | 1(references) | 1(references) |
GA | 21 (13.9) | 18 (11) | 0.78 (0.41-1.50) | 0.78 (0.39-1.54) | 0.84 (0.42-1.78) | ||
0.48 | p = 0.47 | p = 0.66 | |||||
AA | 1 (0.6) | 0 | 1 (0.0001) | 1 (0.0001) | 1 (0.0001) | ||
p = 1 | p = 1 | p = 1 | |||||
Dominant | GG | 134 (85.9) | 146 (89) | 1(references) | 1(references) | 1(references) | |
GA/AA | 22 (14.1) | 18 (11) | 0.75 (0.39-1.46) | 0.74 (0.37-1.45) | 0.79 (0.37-1.65) | ||
p = 0.39 | p = 0.38 | p = 0.53 | |||||
Recessive | AA | 1 (0.6) | 0 | 1(references) | 1(references) | 1(references) | |
GA/GG | 155 (99.4) | 164 (100) | 1 (0.0001) | 1 (0.0001) | 1 (0.0001) | ||
p = 1 | p = 1 | p = 1 | |||||
Alleles | G | 289 (92.6) | 310 (94.5) | – | – | – | |
A | 23 (7.7) | 18 (5.5) | – | – | – | ||
Hha.rs3 SNP | Additive | CC | 93 (62) | 102 (62.2) | 1(references) | 1(references) | 1(references) |
CG | 49 (32.7) | 50 (30.5) | 0.93 (0.57-1.50) | 0.97 (0.59-1.59) | 1.04 (0.61-1.77) | ||
p = 0.79 | p = 0.92 | p = 0.86 | |||||
GG | 8 (5.3) | 12 (7.3) | 1.43 (0.55-3.67) | 1.32 (0.51-3.42) | 1.63 (0.60-4.45) | ||
p = 0.45 | p = 0.56 | p = 0.33 | |||||
Dominant | CC | 93 (62) | 102 (62.2) | 1(references) | 1(references) | 1(references) | |
CG/GG | 57 (38) | 62 (37.8) | 1 (0.62-1.61) | 1.02 (0.64-1.63) | 1.12 (0.68-1.85) | ||
p = 0.99 | p = 0.90 | p = 0.39 | |||||
Recessive | CG/CC | 142 (94.7) | 152 (92.7) | 1(references) | 1(references) | 1(references) | |
GG | 8 (5.3) | 12 (7.3) | 1.46 (0.58-3.70) | 1.40 (0.55-3.59) | 1.60 (0.60-4.3) | ||
p = 0.47 | p = 0.48 | p = 0.34 | |||||
Alleles | C | 235 (78.3) | 254 (77.4) | – | – | – | |
G | 65 (21.7) | 74 (22.6) | – | – | – | ||
BST1107.rs4 SNP | Additive | TT | 149 (55.5) | 157 (95.2) | 1(references) | 1(references) | 1(references) |
CT | 6 (3.9) | 8 (4.8) | 1.25 (0.42-3.70) | 1.43 (0.47-4.30) | 2.18 (0.69-6.45) | ||
p = 0.67 | p = 0.52 | p = 0.18 | |||||
CC | 1 (0.6) | 0 | 0.0001 (0.0001) | 0.0001 (0.0001) | 0.0001 (0.0001) | ||
p = 1 | p = 1 | p = 1 | |||||
Dominant | TT | 149 (95.5) | 156 (95.1) | 1(references) | 1(references) | 1(references) | |
CT/CC | 7 (4.5) | 8 (4.9) | 1.12 (0.39-3.18) | 1.23 (0.42-3.56) | 1.82 (0.61-5.43) | ||
p = 0.82 | p = 0.69 | p = 0.28 | |||||
Recessive | TT/CT | 155 (99.4) | 164 (100) | 1(references) | 1(references) | 1(references) | |
CC | 1 (0.6) | 0 | 0.0001 (0.0001) | 0.0001 (0.0001) | 0.0001 (0.0001) | ||
p = 1 | p = 1 | p = 1 | |||||
Alleles | T | 304 (97.5) | 322 (98.2) | – | – | – | |
C | 8 (2.5) | X | – | – | – |