Skip to main content

Table 3 Multivariate logistic regression analyses of serum EV ARG 1 levels and different duration of T2DM

From: Elevated serum extracellular vesicle arginase 1 in type 2 diabetes mellitus: a cross-sectional study in middle-aged and elderly population

EV ARG 1 (per 10 pg/mL increase)

No. of patients

Unadjusted

Model 1

Model 2

Model 3

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

Total

103

1.318 (1.165–1.492)

< 0.001

1.376 (1.194–1.585)

< 0.001

1.450 (1.135–1.851)

0.003

1.388 (1.155–1.669)

< 0.001

Non-T2DM (Reference)

18

1.000

1.000

1.000

1.000

Prediabetes

12

0.857 (0.711–1.034)

0.107

0.880 (0.729–1.063)

0.184

0.889 (0.694–1.139)

0.239

0.897 (0.696–1.157)

0.831

< 4, years

24

1.177 (1.007–1.374)

0.040

1.220 (1.025–1.453)

0.025

1.230 (1.014–1.492)

0.036

1.194 (1.001–1.424)

0.048

4–10, years

26

1.213 (1.051–1.400)

0.008

1.417 (1.065–1.886)

0.017

1.400 (1.071–1.829)

0.014

1.425 (1.098–1.850)

0.008

> 10, years

23

1.386 (1.101–1.743)

0.005

1.488 (1.109–1.997)

0.008

1.734 (1.040–2.890)

0.035

1.651 (1.066–2.557)

0.025

  1. EV Extracellular vesicles, T2DM Type 2 diabetes mellitus, ARG 1 Arginase 1, SBP Systolic blood pressure, BMI Body Mass Index, TG Triglyceride, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, hs-CRP High-sensitivity C-reactive protein, OR Odds Ratio, CI Confidence Interval
  2. Model 1: adjusted for age, sex, and BMI;
  3. Model 2: adjusted for Model 1 + smoke, drink, SBP, TC, TG, hs-CRP
  4. Model 3: adjusted for Model 2 + coronary heart disease
  5. *p < 0.05, **p < 0.001