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Table 2 Risk factors of subclinical hypothyroidism among total subjects, subjects with positive thyroid autoantibodies, and subjects with negative autoantibodies

From: Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study

 

Total subjects

Subjects with positive thyroid autoantibodies

Subjects with negative autoantibodies

OR(95%CI)

P

OR(95%CI)

P

OR(95%CI)

P

Univariate logistic analysis

 Sex

1.540 (1.106,2.144)

0.011

1.790 (0.847,3.780)

0.127

1.170 (0.791,1.730)

0.431

 Age

1.290 (0.839,1.981)

0.246

1.904 (0.489,2.445)

0.827

1.413 (0.846,2.360)

0.186

 Smoking

0.250 (0.135,0.464)

< 0.001

0.391 (0.118,1.300)

0.126

0.253 (0.122,0.525)

< 0.001

 Obesity

1.552 (1.007,2.390)

0.046

2.176 (1.090,4.344)

0.027

1.206 (0.676,2.153)

0.526

 Diabete mellitus

0.973 (0.502,1.887)

0.936

3.316 (0.437,25.132)

0.246

0.694 (0.342,1.407)

0.311

 Hypertension

0.950 (0.664,1.358)

0.778

0.967 (0.509,1.839)

0.919

0.936 (0.604,1.450)

0.766

 Urinary iodine concentration

1.001 (1.000,1.001)

0.061

1.000 (0.999,1.002)

0.398

1.001 (1.000,1.001)

0.094

 TPO-Ab

3.187 (2.195,4.628)

< 0.001

 Tg-Ab

3.206 (2.262,4.542)

< 0.001

Multiple logistic analysis

 Sex

0.820 (0.567,1.185)

0.291

1.857 (0.872,3.958)

0.109

 Age

1.277 (0.823,1.982)

0.275

1.155 (0.509,2.621)

0.730

 Smoking

0.248 (0.127,0.482)

< 0.001

 Obesity

1.542 (0.988,2.407)

0.057

2.212 (1.103,4.433)

0.025

 TPO-Ab

1.924 (1.190,3.110)

0.008

 Tg-Ab

2.053 (1.303,3.236)

0.002

  1. Univariate logistic regression, when adjusted for sex (male and female), age (<65y and ≥ 65y), smoking status (non-smoking and smoking), obesity (no and yes), diabetes mellitus (no and yes), hypertension (no and yes), urinary iodine concentration (continuous variable), TPO-Ab (negativity and positivity) and Tg-Ab (negativity and positivity) was used for identify the associated risk factors for subclinical hypothyroidism among the total subjects, subjects with positive thyroid autoantibodies, and subjects with negative autoantibodies, respectively. Factors that differed in the univariate logistic analysis were further analysed in the multiple logistic analysis. P < 0.05 was considered significant
  2. TPO-Ab Thyroid peroxidase antibody, Tg-Ab Thyroglobulin antibody