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Table 3 Associations between the SNPs of Sirt1 and Nrf2 gene and the risk of MetS

From: Association of genetic variants in the Sirt1 and Nrf2 genes with the risk of metabolic syndrome in a Chinese Han population

   MetS N (%) non-MetSaN(%) Crude OR (95% CI) Adjusted OR (95% CI)b
rs7895833 GG 74 (52.5) 275 (51.3) 1.00(ref.) 1.00(ref.)
AG 48 (34) 237 (41.5) 2.042(0.97-2.224)* 1.937(1.09-2.144)*
AA 19 (13.5) 37 (7.3) 2.508(1.21-3.637)* 2.414(1.37-3.512)*
rs2273773 TT 82 (58.1) 293 (53.4) 1.00(ref.) 1.00(ref.)
CT 51 (36.2) 231 (42.1) 0.784(0.284-1.617) 0.668(0.314-1.746)
CC 8 (5.7) 25 (4.5) 1.120(0.486-2.582) 1.037(0.237-1.795)
rs6721961 AA 72 (51.1) 305 (54.8) 1.00(ref.) 1.00(ref.)
CA 60 (42.5) 208 (38.4) 1.226(0.526-2.529) 1.062(0.533-1.804)
CC 9 (6.4) 36 (6.8) 1.074(0.435-2.048) 0.955(0.459-2.012)
  1. Bold indicated significant correlation
  2. aThe observed genotype frequencies of SNPs among the non-MetS were all in agreement with the Hardy–Weinberg equilibrium (P > 0.05 for all)
  3. bBinary logistic regression with age, sex, smoking and drinking as covariables was used to calculate the adjusted ORs as well as the 95% confidence intervals (95% CIs)
  4. * P < 0.05