Association of genetic variants in the Sirt1 and Nrf2 genes with the risk of metabolic syndrome in a Chinese Han population

Table 3 Associations between the SNPs of Sirt1 and Nrf2 gene and the risk of MetS

		MetS N (%)	non-MetS^aN(%)	Crude OR (95% CI)	Adjusted OR (95% CI)^b
rs7895833	GG	74 (52.5)	275 (51.3)	1.00(ref.)	1.00(ref.)
	AG	48 (34)	237 (41.5)	2.042(0.97-2.224)*	1.937(1.09-2.144)*
	AA	19 (13.5)	37 (7.3)	2.508(1.21-3.637)*	2.414(1.37-3.512)*
rs2273773	TT	82 (58.1)	293 (53.4)	1.00(ref.)	1.00(ref.)
	CT	51 (36.2)	231 (42.1)	0.784(0.284-1.617)	0.668(0.314-1.746)
	CC	8 (5.7)	25 (4.5)	1.120(0.486-2.582)	1.037(0.237-1.795)
rs6721961	AA	72 (51.1)	305 (54.8)	1.00(ref.)	1.00(ref.)
	CA	60 (42.5)	208 (38.4)	1.226(0.526-2.529)	1.062(0.533-1.804)
	CC	9 (6.4)	36 (6.8)	1.074(0.435-2.048)	0.955(0.459-2.012)

Bold indicated significant correlation
^aThe observed genotype frequencies of SNPs among the non-MetS were all in agreement with the Hardy–Weinberg equilibrium (P > 0.05 for all)
^bBinary logistic regression with age, sex, smoking and drinking as covariables was used to calculate the adjusted ORs as well as the 95% confidence intervals (95% CIs)
^* P < 0.05

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