No. | Study | Age (yr) | IP/HP | Clinical presentation | Gonadal function | Uterine size (cm) | Tumor size (cm) | Pathology | Tx | RTc |
---|---|---|---|---|---|---|---|---|---|---|
Isosexual precocity | ||||||||||
1 | Present case | 1 | IP | Breast development Nipples hyperpigmentation Pubic hair growth | FSH < 0.1 IU/La LH < 0.1 IU/La E2 2420.9 pmol/La | 3.57 × 1.47 × 1.96 | 4.2 × 2.5 × 1.4 | Polygonal tumor cells with abundant cytoplasm ranging from vacuolated (lipid-rich) to eosinophilic (lipid-poor) | SO | 5 months |
2 | Haroon et al., 2015 [4] | 3 | IP | Breast development Vaginal bleeding | NA | NA | 7.0 | NA | SO | NA |
3 | Lin et al., 2000 [5] | 3 | IP | Breast development Pubic hair growth Vaginal bleeding | FSH < 1.0 IU/La LH < 0.6 IU/La E2 348.8 pmol/La Testosterone 1.2 nmol/La 17-OHP 3.9 nmol/L DHEA-S 3.1 μmol/L | 6.2 × 3.2 × 2.2 | 4.4 × 4.1 × 3.2 | NA | Resection of ovary | 6 months |
4 | Lee et al., 2011 [6] | 8 | IP | Breast development Pubic hair growth Vaginal spotting Hypertension | FSH < 0.1 IU/La LH 0.29 IU/La E2 1066.1 pmol/La Aldosterone 2.3 nmol/L Angiotensin 124.0 pmol/L | NA | 5.1 × 4.0 | The ovarian tumor had sheets of clear or eosinophilic cells surrounded with a delicate fibrous stroma. | SO | 16 months |
Heterosexual precocity | ||||||||||
5 | Hellyanti et al., 2021 [7] | 2 | HP | Cushing’s syndrome Virilization Hypertension | Cortisol 733.89 nmol/L Normal lutropin, gonadotropin and AFP | NA | 5.0 × 4.2 ×  3.5 | The tumor comprised polygonal cells with distinct cellular borders and abundant, clear-to-granular eosinophilic cytoplasm. | SO | NA |
6 | Yoshimatsu et al., 2020 [8] | 4 | HP | Cushing’s syndrome Virilization | Testosterone 8.4 nmol/Lb ACTH 0.3 pmol/L Cortisol 593.1 nmol/L LDH 6.07 ukat/L NSE 36.6 μg/L | NA | 8.0 × 5.0 × 5.0 | The tumor was composed of both eosinophilic and vacuolated cytoplasm. | SO and C/T | 4 months |
7 | Qian et al., 2016 [9] | 5 | NA | Abdominal pain Vomiting | AFP 1.15 μg/L β-HCG < 0.10 IU/L CA-125 37.71 kU/L CA19–9 30.25 kU/L | NA | 8.0 × 4.0 × 7.0 | The tumor was composed of cells with abundant eosinophilic to clear cytoplasm and round nuclei with prominent nucleoli | SO and C/T | No recurrence within 5 years |
8 | Gupta et al., 2008 [10] | 5 | HP | Cushing’s syndrome Facial acnes Hirsutism Hypertrichosis | E2 275.4 pmol/Lb Testosterone 9.2 nmol/Lb Progesterone 46.1 nmol/L Cortisol 913.1 nmol/L | NA | NA | The cells had abundant eosinophilic cytoplasm and were strongly positive for inhibin immunostain. | Tumor excision | 4 months |
9 | Sawathiparnich et al., 2009 [11] | 6 | HP | Cushing’s syndrome | Testosterone 1.9 nmol/Lb ACTH 88.6 pmol/L Cortisol 1073.9 nmol/L DHEA-S 4.2 μmol/L CA-125 95.68 kU/L NSE 404.8 μg/L | NA | 7 × 6 × 5 | The ovarian tissue was replaced by nests or cords of round to polygonal cells with eosinophilic cytoplasm, mild nuclear atypia, and frequent intranuclear inclusions. | SO | 8 months |
10 | Harris et al., 1991 [12] | 8 | HP | Virilization | NA | NA | NA | NA | Tumor excision | NA |
11 | Yılmaz-Ağladıoğlu et al., 2013 [13] | 13 | HP | Virilization | FSH 4.7 IU/La LH 1.7 IU/La E2 154.2 pmol/La Testosterone 5.1 nmol/La 17-OHP 58.4 nmol/L ACTH 1.6 pmol/L DHEA-S 3.0 μmol/L | 6.9 × 2.4 × 0.9 | 2.3 × 2.2 | Moderately pleomorphic neoplasm without mitoses or necrosis, which was surrounded by a fibrous capsule with the intact surrounding ovarian tissue | SO | 6 months |
12 | Boyraz et al., 2013 [14] | 16 | HP | Amenorrhea Virilization | Testosterone 3.3 nmol/Lb LDH 5.2 ukat/L | NA | 6 × 4 × 3.3 | Minor fibromatous component and areas of hyalinization were also present. | Ovarian cystectomy | 4 months |
13 | Ding and Hsu., 2007 [15] | 16 | HP | Amenorrhea Facial hirsutism Temporal balding Virilization | NA | NA | 5.7 × 6.3 × 5.5 | NA | Ovarian cystectomy | NA |
14–16 | Hayes and Scully, 1987 [2] | 2–15 (3 case) | IP/HP | NA | NA | NA | NA | NA | NA | NA |