The effect of parathyroidectomy compared to non-surgical surveillance on kidney function in primary hyperparathyroidism: a nationwide historic cohort study

Table 2 Baseline to follow-up

	Non-PTX		PTX
	Baseline	Follow-up	Baseline	Follow-up	p
All	(n = 1608)		(n = 1977)
P-Creatinine, μmol/L	79 (65;98)	79 (65;98) *	73 (63;87)	76 (65;90) *	< 0.001
eGFR, mL/min	69 (52;86)	69 (51;86) *	81 (66;95)	79 (63;93) *	< 0.001
eGFR < 60 mL/min	(n = 593)		(n = 344)
P-Creatinine, μmol/L	105 (90;127)	105 (88;126)	105 (91;129)	105 (88;130)	0.906
eGFR, mL/min	46 (36;54)	46 (37;56) *	51 (41;56)	50 (39;58) *	0.756
eGFR ≥ 60 mL/min	(n = 1015)		(n = 1633)
P-Creatinine, μmol/L	69 (60;77)	69 (60;80) *	70 (61;79)	72 (63;83) *	0.002
eGFR, mL/min	82 (71;92)	82 (70;92) *	86 (74;97)	84 (72;95) *	< 0.001
Mild Hypercalcemia^a	(n = 1159)		(n = 890)
P-Creatinine, μmol/L	77 (64;96)	78 (64;97) *	72 (62;85)	74 (64;88) *	0.001
eGFR, mL/min	72 (53;88)	72 (53;88) *	82 (67;95)	79 (65;92) *	< 0.001
Moderate-severe Hypercalcemia^a	(n = 342)		(n = 936)
P-Creatinine, μmol/L	84 (67;104)	83 (66;106)	74 (63;90)	77 (65;92) *	0.002
eGFR, mL/min	64 (47;80)	63 (46;81)	81 (64;95)	77 (62;92) *	0.008

Results listed as median with interquartile range (25%;75%)
p-values shows results of statistical tests comparing PTX-treated and non-PTX-treated, regarding the percentage difference from baseline to follow-up. p < 0.05 is considered as significant
A significant within group change from baseline to follow-up is marked by *
Baseline: Time of diagnosis
Follow-up: 9–15 months after respectively time of diagnosis for non-PTX group and PTX for PTX group
Abbreviations: PTX parathyroidectomy, eGFR estimated glomerular filtration rate
^aMild hypercalcemia is defined as plasma levels of ionized calcium above upper limit of normal but below 1.45 mmol/L. Moderate to severe hypercalcemia is defined as ionized calcium levels ≥1.45 mmol/L. Due to missing values of ionized calcium levels at baseline, number of subjects are slightly below the number stated in Fig. 1

ISSN: 1472-6823