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Table 2 Stratified analyses of IL-6 and IL-10 genes’ common polymorphisms on cirrhosis of liver risk

From: IL-6 and IL-10 gene polymorphisms and cirrhosis of liver risk from a comprehensive analysis

Variables

N

Case/

Allelic contrast

Heterozygote comparison

Dominant model

  

Control

OR(95%CI) Ph P I-squared

OR(95%CI) Ph P I-squared

OR(95%CI) Ph P I-squared

IL-10 -592

     

Total

19

2019/2403

1.15 (0.98–1.37)0.000 0.093 65.7%

1.30 (1.01–1.67)0.006 0.03950.9%

1.34 (1.04–1.72)0.001 0.02157.5%

Ethnicity

     

Asian

13

1506/1867

1.25 (1.01–1.55)0.000 0.042 72.3%

1.40 (1.03–1.88)0.001 0.02963.1%

1.47 (1.09–1.99)0.000 0.01368.3%

Caucasian

4

426/384

0.98 (0.78–1.22)0.270 0.840 23.4%

1.26 (0.74–2.14)0.728 0.399 0.0%

1.24 (0.76–2.02)0.747 0.395 0.0%

SOC

     

HB

14

1483/1790

1.19 (0.95–1.48)0.000 0.125 73.6%

1.36 (0.98–1.89)0.001 0.06863.5%

1.40 (1.01–1.96)0.000 0.04668.2%

PB

5

536/613

1.11 (0.93–1.33)0.594 0.234 0.0%

1.17 (0.88–1.57)0.917 0.277 0.0%

1.19 (0.91–1.56)0.897 0.208 0.0%

Disease type

     

PBC

5

484/498

1.11 (0.91–1.35)0.590 0.319 0.0%

1.23 (0.85–1.78)0.908 0.281 0.0%

1.27 (0.89–1.79)0.871 0.184 0.0%

HBV-LC

6

466/730

1.46 (0.86–2.49)0.000 0.163 35.9%

2.24 (0.95–5.28)0.000 0.06584.0%

2.26 (0.95–5.38)0.000 0.06586.3%

HCV-LC

4

222/311

0.98 (0.75–1.28)0.161 0.901 41.8%

0.93 (0.53–1.64)0.531 0.794 0.0%

0.98 (0.59–1.62)0.572 0.926 0.0%

-819

     

Total

12

1134/1549

1.07 (0.88–1.30)0.017 0.485 52.4%

1.14 (0.86–1.51)0.072 0.35440.3%

1.15 (0.86–1.53)0.029 0.35448.8%

Ethnicity

     

Asian

9

938/1304

1.05 (0.82–1.34)0.006 0.089 63.0%

1.18 (0.86–1.64)0.047 0.30449.0%

1.17 (0.83–1.64)0.016 0.36757.2%

Caucasian

2

159/143

1.28 (0.90–1.83)0.790 0.173 0.0%

1.23 (0.64–2.34)0.542 0.537 0.0%

1.33 (0.74–2.39)0.493 0.334 0.0%

SOC

     

HB

7

608/922

1.14 (0.88–1.47)0.037 0.321 55.2%

1.22 (0.78–1.91)0.020 0.38660.2%

1.23 (0.80–1.91)0.016 0.34361.5%

PB

5

526/627

0.96 (0.68–1.36)0.045 0.832 58.9%

1.07 (0.81–1.42)0.543 0.614 0.0%

1.08 (0.83–1.40)0.229 0.556 28.8%

Disease type

     

PBC

4

313/357

1.24 (0.97–1.57)0.964 0.082 0.0%

1.37 (0.95–1.99)0.906 0.095 0.0%

1.38 (0.97–1.96)0.911 0.071 0.0%

HBV-LC

3

138/406

1.55 (0.55–4.43)0.004 0.409 81.6%

2.96 (0.70–12.47)0.0320.14070.8%

2.68 (0.67–10.74)0.0240.16573.2%

HCV-LC

2

133/212

0.92 (0.66–1.27)0.901 0.595 0.0%

0.65 (0.38–1.14)0.457 0.132 0.0%

0.71 (0.42–1.20)0.467 0.203 0.0%

-1082

     

Total

18

1741/2776

1.01 (0.85–1.20)0.013 0.892 47.5%

1.01 (0.82–1.23)0.202 0.941 21.2%

1.00 (0.80–1.24)0.053 0.971 37.9%

Ethnicity

     

Asian

12

1412/2103

0.94 (0.76–1.17)0.018 0.577 51.9%

1.01 (0.78–1.33)0.092 0.921 37.5%

0.96 (0.72–1.29)0.024 0.795 50.2%

Caucasian

3

220/473

1.25 (0.94–1.65)0.323 0.122 11.4%

1.20 (0.78–1.85)0.900 0.409 0.0%

1.30 (0.86–1.95)0.699 0.213 0.0%

African

2

72/98

1.27 (0.82–1.97)0.817 0.282 0.0%

1.12 (0.47–2.70)0.241 0.799 27.2%

1.24 (0.55–2.82)0.269 0.602 18.0%

SOC

     

HB

10

902/1797

1.04 (0.89–1.21)0.502 0.601 0.0%

1.11 (0.90–1.37)0.734 0.319 0.0%

1.09 (0.90–1.32)0.683 0.380 0.0%

PB

8

839/979

0.99 (0.72–1.36)0.005 0.966 65.8%

0.86 (0.56–1.33)0.087 0.505 43.7%

0.87 (0.53–1.42)0.016 0.577 59.3%

Disease type

     

PBC

5

374/687

1.30 (1.01–1.68)0.568 0.043 0.0%

1.32 (0.93–1.89)0.901 0.122 0.0%

1.39 (0.98–1.95)0.863 0.061 0.0%

HBV-LC

5

297/611

0.97 (0.71–1.32)0.318 0.827 15.2%

1.30 (0.89–1.90)0.527 0.170 0.0%

1.15 (0.80–1.67)0.420 0.447 0.0%

HCV-LC

4

205/310

0.98 (0.76–1.28)0.547 0.897 0.0%

0.81 (0.53–1.24)0.865 0.332 0.0%

0.85 (0.58–1.26)0.489 0.414 0.0%

LC

2

559/572

0.72 (0.60–0.85)0.987 0.000 0.0%

0.64 (0.44–0.93)0.865 0.019 0.0%

0.56 (0.39–0.80)0.892 0.001 0.0%

IL-6 -174

     

Total

6

590/861

1.17 (0.73–1.86)0.002 0.511 77.5%

1.42 (0.70–2.87)0.000 0.330 78.3%

1.37 (0.71–2.63)0.001 0.346 77.2%

Ethnicity

     

Caucasian

3

410/501

0.89 (0.73–1.09)0.631 0.244 0.0%

0.87 (0.65–1.15)0.314 0.316 13.7%

0.86 (0.66–1.12)0.550 0.257 0.0%

SOC

     

HB

3

198/305

1.98 (0.55–7.05)0.001 0.294 86.8%

2.79 (0.41–18.88)0.000 0.294 90.4%

2.71 (0.47–15.57)0.0000.26589.6%

PB

3

392/556

0.99 (0.63–1.55)0.083 0.961 59.8%

1.04 (0.76–1.42)0.130 0.800 50.9%

0.98 (0.73–1.32)0.110 0.916 54.7%

−572

     

Total

4

1131/864

1.15 (0.97–1.36)0.859 0.117 0.0%

2.23 (0.80–6.21)0.000 0.127 89.2%

1.60 (0.83–3.06)0.005 0.157 76.3%

−597

     

Total

2

280/374

0.84 (0.66–1.08)0.453 0.168 0.0%

0.88 (0.63–1.23)0.203 0.462 38.3%

0.84 (0.61–1.15)0.278 0.283 15.0%

  1. Ph: value of Q-test for heterogeneity test; P: Z-test for the statistical significance of the OR