IL-6 and IL-10 gene polymorphisms and cirrhosis of liver risk from a comprehensive analysis

Zheng, Minghui; Fang, Weizhen; Yu, Menglei; Ding, Rui; Zeng, Hua; Huang, Yan; Mi, Yuanyang; Duan, Chaohui

doi:10.1186/s12902-021-00906-3

BMC Endocrine Disorders

Table 1 Characteristics of included studies about polymorphisms in IL-6 and IL-10 genes and cirrhosis of liver risk

From: IL-6 and IL-10 gene polymorphisms and cirrhosis of liver risk from a comprehensive analysis

Author	Year	Country	Ethnicity	Case	Control	SOC	HWE	Genotype	Sub-type
-592	rs1800872
Chen	2004	China	Asian	77	54	HB	0.633	PCR-RFLP	PBC
Zappala	1998	UK	Caucasian	171	141	HB	0.071	PCR	PBC
Matsushita	2002	USA	Caucasian	94	72	PB	0.501	PCR-RFLP	PBC
Matsushita	2002	USA	Caucasian	65	71	PB	< 0.01	PCR-RFLP	PBC
Marcos	2008	Spain	Caucasian	96	100	HB	0.093	PCR-RFLP	ALC
Yao	2015	China	Asian	318	318	PB	< 0.01	PCR-RFLP	LC
Barooah	2020	India	Asian	96	110	HB	0.009	PCR-RFLP	HCV-LC
Liu	2015	China	Asian	192	192	HB	< 0.01	Sequenom Assay Design	Mixed
Cao	2016	China	Asian	241	254	HB	< 0.01	PCR-RFLP	LC
Baghi	2015	Iran	Asian	9	102	PB	0.664	PCR-RFLP	HBV-LC
Cheong	2005	South Korea	Asian	79	261	HB	< 0.01	PCR	HBV-LC
Sheneef	2017	Egypt	African	50	50	PB	0.889	ARMS-PCR	HCV-LC
Corchado	2013	Korea	Asian	39	49	HB	0.187	PCR	HCV-LC
Fan	2004	China	Asian	77	160	HB	< 0.01	PCR-RFLP	PBC
Khalifa	2016	Saudi Arabia	Asian	109	110	HB	0.525	PCR-RFLP	HBV-LC
Moreira	2016	Brazil	Mixed	37	102	HB	0.316	PCR-SSP	HCV-LC
Wang	2010	China	Asian	50	42	HB	< 0.01	PCR	HBV-LC
Jiang	2009	China	Asian	169	119	HB	0.552	PCR-RFLP	HBV-LC
Wu	2010	China	Asian	50	96	HB	0.125	PCR-RFLP	HBV-LC
−819	rs1800871
Chen	2004	China	Asian	77	54	HB	1	PCR-RFLP	PBC
Matsushita	2002	USA	Caucasian	94	72	PB	0.501	PCR-RFLP	PBC
Matsushita	2002	USA	Caucasian	65	71	PB	0.049	PCR-RFLP	PBC
Yao	2015	China	Asian	318	318	PB	0.227	PCR-RFLP	LC
Barooah	2020	India	Asian	96	110	HB	0.474	PCR-RFLP	HCV-LC
Liu	2015	China	Asian	192	192	HB	0.073	Sequenom Assay Design	Mixed
Baghi	2015	Iran	Asian	9	102	PB	0.369	PCR-RFLP	HBV-LC
Cheong	2005	South Korea	Asian	79	261	HB	0.458	PCR	HBV-LC
Yang	2013	China	Asian	40	64	PB	0.821	ARMS-PCR	ALC
Fan	2004	China	Asian	77	160	HB	0.455	PCR-RFLP	PBC
Moreira	2016	Brazil	Mixed	37	102	HB	0.316	PCR-SSP	HCV-LC
Wang	2010	China	Asian	50	43	HB	0.017	PCR	HBV-LC
−1082	rs1800896
Chen	2004	China	Asian	77	54	HB	0.611	PCR-RFLP	PBC
Bathgate	2000	UK	Caucasian	61	330	HB	0.003	sequence	PBC
Matsushita	2002	USA	Caucasian	94	72	PB	0.859	PCR-RFLP	PBC
Matsushita	2002	USA	Caucasian	65	71	PB	0.568	PCR-RFLP	PBC
Abd El-Baky	2020	Egypt	African	22	48	PB	< 0.01	TaqMan real-time PCR	HCV-LC
Yao	2015	China	Asian	318	318	PB	0.898	PCR-RFLP	LC
Barooah	2020	India	Asian	96	110	HB	0.054	PCR-RFLP	HCV-LC
Liu	2015	China	Asian	266	532	HB	< 0.01	Sequenom Assay Design	Mixed
Cao	2016	China	Asian	241	254	PB	0.953	PCR-RFLP	LC
Baghi	2015	Iran	Asian	9	102	PB	0.047	PCR-RFLP	HBV-LC
Cheong	2005	South Korea	Asian	79	261	HB	0.769	PCR	HBV-LC
Yang	2013	China	Asian	40	64	PB	0.452	ARMS-PCR	ALC
Sheneef	2017	Egypt	African	50	50	PB	0.259	ARMS-PCR	HCV-LC
Fan	2004	China	Asian	77	160	HB	0.505	PCR-RFLP	PBC
Khalifa	2016	Saudi Arabia	Asian	109	110	HB	0.267	PCR-RFLP	HBV-LC
Moreira	2016	Brazil	Mixed	37	102	HB	0.973	PCR-SSP	HCV-LC
Wang	2010	China	Asian	50	42	HB	0.874	PCR	HBV-LC
Wu	2010	China	Asian	50	96	HB	0.629	PCR-RFLP	HBV-LC
-174G > C
Giannitrapani	2011	Italy	Caucasian	95	105	HB	0.776	PCR-RFLP	LC
Fan	2004	China	Asian	77	160	PB	< 0.01	SSP	PBC
Falleti	2008	Italy	Caucasian	219	236	PB	0.536	PCR-RFLP	Mixed
Marcos	2009	Spain	Caucasian	96	160	PB	0.333	TaqMan	ALC
Motawi	2016	Egypt	African	65	100	HB	< 0.01	PCR-RFLP	HCV-LC
Moreira	2016	Brazil	Mixed	38	100	HB	0.718	PCR-SSP	HCV-LC
IL6–572
Park	2003	Korea	Asian	696	280	PB	0.193	sequence	HBV-LC
Falleti	2008	Italy	Caucasian	219	236	PB	0.249	PCR-RFLP	Mixed
Saxenas	2014	India	Asian	63	83	HB	< 0.01	PCR-RFLP	HBV-LC
Tang	2013	China	Asian	153	265	HB	0.529	TaqMan	HBV-LC
597G > A
Falleti	2008	Italy	Caucasian	219	236	PB	0.348	PCR-RFLP	Mixed
Saxenas	2014	India	Asian	3	138	HB	0.613	PCR-RFLP	HBV-LC

HB: hospital-based; PB: population-based; SOC; source of control; PCR-RFLP: polymerase chain reaction followed by restriction fragment length polymorphism; SSP: sequence specific primer; ARMS: amplification refractory mutation system; HWE: Hardy-Weinberg equilibrium of control group; PBC: primary biliary cirrhosis; LC: liver cirrhosis; ALC: alcoholic liver cirrhosis, HCV: hepatitis C virus infection, HBV: hepatitis B virus infection

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ISSN: 1472-6823

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