Fig. 1
From: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas
Bromocriptine upregulates DRD2 levels and reduces MAPK11/12/13/14 and PRL levels in rat prolactinomas. a Analysis of the appearance of the pituitary in the Control, Prolactinoma, and BRC groups. b Ratio of pituitary weight to body weight in rats,****P < 0.0001 vs. Control;####P < 0.0001 vs. Prolactinoma, (n = 10). c Detection of serum PRL level in rats by ELISA.***P < 0.001 vs. Control; ###P < 0.001 vs. Prolactinoma,(n = 6). d The protein expression levels of DRD2, MAPK11, MAPK12, MAPK13, MAPK14 and PRL in rat pituitary were detected by western blot. e The expression levels of DRD2, MAPK11, MAPK12, MAPK13, MAPK14 and PRL mRNA in rat pituitary were detected by RT-qPCR.*p < 0.05 vs. control, ***p < 0.001 vs. control, #p < 0.05 vs. prolactinoma,###p < 0.001 vs. Prolactinoma,(n = 3)