Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

Table 6 Hazard ratios of acute cardiac injury according to different FT3 categories among patients with COVID-19

	No of participants	No. of cases	Person-days	Hazard ratios (95% confidence intervals)
	No of participants	No. of cases	Person-days	Model 1	Model 2	Model 3
Acute cardiac injury
Normal FT3^a,	205	33	6396	1.00	1.00	1.00
Low FT3^b	30	17	916	2.39 (1.20–4.77)	2.47 (1.13–5.37)	3.46 (1.90–6.31)

Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, smoking, systolic blood pressure, fasting glucose, using antihypertensive drugs, and using glucose-lowering drug. Model 3 adjusted for total cholesterol and using lipid-lowering agents. ^aNormal FT3 was defined as FT3 within 2.63–5.7 pmol/L. ^bLow FT3 was defined as FT3 < 2.63 pmol/L. Abbreviations: COVID-19 coronavirus disease 2019, FT3 Free Triiodothyronine

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