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Table 5 Hazard ratios of acute cardiac injury according to different thyroid function categories among patients with COVID-19

From: Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

 

No of participants

No. of cases

Person-days

Hazard ratios (95% confidence intervals)

Model 1

Model 2

Model 3

Acute cardiac injury

 NTF

184

27

5753

1.00

1.00

1.00

 Subclinical hypothyroidism

17

4

524

1.68 (0.58–4.86)

1.68 (0.56–5.05)

1.97 (0.67–5.78)

 Severe NTIS

11

7

350

3.78 (1.57–9.14)

4.68 (1.76–12.4)

4.20 (1.78–9.90)

 Mild to moderate NTIS

23

12

685

2.50 (1.13–5.52)

2.63 (1.09–6.36)

3.93 (1.96–7.89)

  1. Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, smoking, systolic blood pressure, fasting glucose, using antihypertensive drugs, and using glucose-lowering drug. Model 3 adjusted for total cholesterol and using lipid-lowering agents. Abbreviations: COVID-19 coronavirus disease 2019, NTF Normal thyroid function, NTIS Non-thyroidal illness syndrome