Skip to main content

Table 5 Hazard ratios of acute cardiac injury according to different thyroid function categories among patients with COVID-19

From: Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

  No of participants No. of cases Person-days Hazard ratios (95% confidence intervals)
Model 1 Model 2 Model 3
Acute cardiac injury
 NTF 184 27 5753 1.00 1.00 1.00
 Subclinical hypothyroidism 17 4 524 1.68 (0.58–4.86) 1.68 (0.56–5.05) 1.97 (0.67–5.78)
 Severe NTIS 11 7 350 3.78 (1.57–9.14) 4.68 (1.76–12.4) 4.20 (1.78–9.90)
 Mild to moderate NTIS 23 12 685 2.50 (1.13–5.52) 2.63 (1.09–6.36) 3.93 (1.96–7.89)
  1. Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, smoking, systolic blood pressure, fasting glucose, using antihypertensive drugs, and using glucose-lowering drug. Model 3 adjusted for total cholesterol and using lipid-lowering agents. Abbreviations: COVID-19 coronavirus disease 2019, NTF Normal thyroid function, NTIS Non-thyroidal illness syndrome