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Table 4 Hazard ratios of combined endpoint events according to different thyroid function categories among patients with COVID-19

From: Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

  No. of participants No. of cases Person-days Hazard ratios (95% confidence intervals)
Model 1 Model 2 Model 3
Combined endpoint events a
 NTF 184 5 5753 1.00 1.00 1.00
 Subclinical hypothyroidism 17 2 524 5.55 (1.01–30.5) 4.04 (0.69–23.8) 7.14 (1.26–40.6)
 Severe NTIS 11 6 350 18.8 (5.05–69.9) 23.1 (5.75–92.8) 22.1 (6.09–79.9)
 Mild to moderate NTIS 23 15 685 21.0 (6.04–72.7) 27.3 (7.07–105.7) 30.1 (9.89–91.3)
  1. Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, smoking, systolic blood pressure, fasting glucose, using antihypertensive drugs, and using glucose-lowering drug. Model 3 adjusted for total cholesterol and using lipid-lowering agents. aCombined endpoint events: The primary end point was a composite of death or using invasive mechanical ventilation or admission to Intensive care unit. Abbreviations: COVID-19 coronavirus disease 2019, NTF Normal thyroid function, NTIS Non-thyroidal illness syndrome