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Table 3 Treatments and outcomes according to different thyroid function categories among patients with COVID-19

From: Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

 

NTF

Subclinical hypothyroidism

Severe NTIS

Mild to moderate NTIS

P values

No. of participants

184

17

11

23

 

Treatments, %

 Antiviral therapy

162 (88.0)

15 (88.2)

8 (72.7)

20 (87.0)

0.455

 Antibiotic therapy

104 (56.5)

8 (47.1)

9 (81.8)

20 (87.0)

0.010

 Use of corticosteroid

37 (20.1)

4 (23.5)

6 (54.5)

12 (52.2)

0.001

 Intravenous immunoglobin

18 (9.8)

3 (17.6)

5 (45.5)

11 (47.8)

< 0.001

 Antihypertensive medicine

56 (30.4)

10 (58.8)

4 (36.4)

9 (39.1)

0.110

 Glucose-lowering medicine

35 (19.0)

1 (5.9)

2 (18.2)

6 (26.1)

0.451

 Lipid-lowering medicine

16 (8.7)

0 (0.0)

1 (9.1)

2 (8.7)

0.686

Illness severity, %

0.005

 Non-severe

45 (24.5)

4 (23.5)

0 (0.0)

0 (0.0)

0.005

 Severe

139 (75.5)

13 (76.5)

11 (100.0)

23 (100.0)

0.005

Complications, %

 ARDS

2 (1.1)

0 (0.0)

1 (9.1)

3 (13.0)

0.009

 Acute cardiac injury

27 (15.3)

4 (23.5)

7 (70.0)

12 (54.5)

< 0.001

 Acute kidney injury

5 (2.7)

0 (0.0)

3 (27.3)

5 (21.7)

< 0.001

 Shock

3 (1.6)

0 (0.0)

4 (36.4)

11 (47.8)

< 0.001

 Hypoalbuminemia (albumin < 30 g/L)

34 (18.6)

4 (23.5)

5 (45.5)

12 (52.2)

0.001

 Coagulopathy

19 (10.9)

0 (0.0)

3 (27.3)

6 (30.0)

0.015

 Length of hospital stay, days

23.4 (0.99)

25.5 (3.23)

24.8 (4.02)

23.1 (2.89)

0.917

  1. Data are means (SE) and are adjusted for age and sex unless otherwise indicated percentages. Abbreviations: COVID-19 coronavirus disease 2019, NTF Normal thyroid function, NTIS Non-thyroidal illness syndrome, ARDS Acute respiratory distress syndrome