Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review

Table 2 Characteristics of patients of hyperglycemia with or without KS and normal glucose tolerance subjects

	HG-KS (n = 5)	HG (n = 5)	NGT (n = 5)	p value
				HG-KS vs HG	HG-KS vs NGT
Age (y)	16.2 ± 3.3	41.2 ± 2.1	34.0 ± 6.2	0.008*	0.009*
BMI (kg/m²)	22.68 ± 2.97	24.82 ± 2.00	22.08 ± 2.50	0.600	0.754
FBG (mmol/L)	5.90 ± 2.04	7.54 ± 3.21	5.22 ± 0.37	0.251	0.754
FINS (μIU/ml)	29.22 ± 26.00	12.66 ± 7.01	8.89 ± 2.62	0.076	0.009*
HOMA-IR	7.47 ± 7.05	5.22 ± 5.47	2.10 ± 0.75	0.175	0.032*
HOMA-β	346.24 ± 202.59	76.64 ± 28.69	103.56 ± 20.07	0.047*	0.047*
ISImatsuda	35.98 ± 13.87	61.17 ± 23.05	88.29 ± 29.67	0.076	0.009*
QUICKI	0.30 ± 0.03	0.32 ± 0.03	0.35 ± 0.02	0.175	0.028*
IAI	0.01 ± 0.005	0.02 ± 0.008	0.02 ± 0.008	0.175	0.028*
AUC_Ins	423.89 ± 254.66	146.06 ± 62.23	179.62 ± 69.83	0.175	0.175
AUC_Glu/AUC_Ins	0.17 ± 0.25	0.31 ± 0.17	0.14 ± 0.05	0.117	0.175

Statistical difference is along the row and p<0.05 was considered significant
*represents significant difference between two groups
Abbreviations: KS Klinefelter syndrome, HG hyperglycemia, NGT normal glucose tolerance, BMI body mass index, FBG fasting blood glucose, FINS fasting serum insulin, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-β homeostasis model assessment of β-cell function, ISI_matsuda insulin sensitivity index proposed by Matsuda et al., QUICKI quantitative insulin sensitivity check index, IAI insulin action index, AUC_Ins area under curve of insulin, AUC_Glu/AUC_Ins ratio of area under curve of glucose and insulin

ISSN: 1472-6823