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Table 4 Multiple regression model for the determinants of serum ANP

From: Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide

Independent variable

Model 1

Model 2

β

SE

Wald

p

OR

β

SE

Wald

p

OR

UAE (mg/24 h)

0.150

0.211

8.227

0.033

1.92 (1.37–2.27)

0.059

0.509

9.231

0.450

1.12 (1.03–2.32)

TNF-α (pg/mL)

0.528

0.254

9.017

< 0.001

2.23 (1.13–2.43)

0.519

0.673

12.187

< 0.001

2.01 (1.45–3.61)

ADP (ug/L)

0.233

0.365

7.157

0.001

2.07 (1.14–2.87)

0.224

0.396

10.172

0.001

2.31 (2.11–3.12)

IL-6 (ng/L)

0.255

0.373

7.651

0.006

2.62 (1.42–3.19)

0.233

0.523

7.894

0.005

2.89 (2.71–3.58)

BUN (mmol/L)

0.127

0.403

9.187

0.032

1.93 (1.60–2.45)

0.041

0.652

8.921

0.592

1.16 (1.11–2.45)

  1. UAE urinary albumin excretion, ANP atrial natriuretic peptide, ADP adiponection, IL-6 interleukin-6, TNF-α tumor necrosis factor-α, BUN blood urea nitrogen
  2. Model 1 is unadjusted for duration of diabetes
  3. Model 2 is adjusted for duration of diabetes
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BMC Endocrine Disorders

ISSN: 1472-6823

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