Table 4 Logistic regression for determining possible predictive factors on surgical remission in the GH-producing pituitary adenoma

 Densely granulated

1.92 (0.64–5.69)

3.21 (0.53–19.30)

 Sparsely granulated

0.92 (0.24–3.46)

0.94 (0.09–10.20)

 Dual Staining

1

1

 Single Staining

1.53 (0.56–4.17)

2.41(0.46–12.48)

 Dual Staining

1

1

 Densely (reference: S)

2.09(0.59–7.45)

 Age

1.02 (0.98–1.07)

 Sex (reference: Male)

2.68 (1.00–7.20)

6.91 (1.08–44.28)

5.13 (0.96–27.40)

 Pre-operative GH

0.95 (0.91–0.99)

0.94 (0.87–1.01)

0.95 (0.88–1.02)

 Pre-operative IGF1

1.00 (0.99–1.00)

 One-day postoperative GH

0.36 (0.21–0.62)

0.33 (0.17–0.67)

0.36 (0.19–0.69)

 Tumor diameter (mm)

0.98 (0.93–1.02)

 Tumor diameter (youden index:1.7)

0.583(0.22–1.52)

 Cavernous sinus invasion

0.23 (0.07–0.75)

0.09 (0.01–0.70)

0.09 (0.01–0.67)

 T2 MRI intensity (reference: iso or hyper)

0.42 (0.09–1.91)

 Ki-67 (reference: ≤3)

0.62 (0.19–2.06)

 P53

0.47 (0.14–1.57)

 Extention of surgery (reference: total resection)

0.016 (0.004–0.073)

 Skill of Surgeon

1.99(0.33–11.88)