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Table 2 Comparison of surgical outcomes among various subtypes of GH- producing pituitary adenoma

From: Association of different pathologic subtypes of growth hormone producing pituitary adenoma and remission in acromegaly patients: a retrospective cohort study

Variables

Single Staining

n = 48 (%67.6)

Dual Staining

n = 23(%32.4)

Total

n = 71(100%)

Densely granulated

n = 34 (%47.9)

Sparsely granulated

n = 14 (%19.7)

Total

n = 48 (%67.6)

  

Random GH levels, ng/ml (IQR) †

1.3(0.7–2.5)

1.45(0.95–6.62)

1.3(0.7–3.5)

1.69(0.85–3.22)

1.5(0.7,-3.5)

Median follow-up, month (IQR)

12(6,24)

12(6,15)

12(6,24)

12(6,24)

12(6,24)

Hypopituitarism, n (%)

 Central hypogonadism

15(44.1)

9(64.3)

24(50)

9(39.1)

33(46.5)

 Diabetes insipidus

15(44.1)

7(50.0)

22(45.8)

9(39.1)

31(43.7)

 Central hypothyroidism

9(26)

7(50)

16(33)

6(26)

22(30)

 Central adrenal insufficiency

3(8.8)

2(14.3)

5(10.4)

1(4.3)

6(8.5)

Cerebrospinal fluid leak, n (%)

3(8.8)

3(21.4)

6(12.5)

0(0)

6(8.5)

Meningitis, n (%)

0(0)

1(7.1)

1(2.1)

0(0)

1(1.4)

Focal neurological deficit, n (%)

0(0)

0(0)

0(0)

0(0)

0(0)

  1. IQR interquartile range
  2. † One day post-operative-GH levels adjusted for age and sex, BMI
  3. *Significant difference among the Single Staining Densely granulated, Single Staining Sparsely granulated, and Dual Staining groups (p < 0.05)
  4. ** Significant difference between the Single Staining, and Dual Staining groups (p < 0.05)