Fig. 3
From: The genomic profiling and MAMLD1 expression in human and canines with Cushing’s disease
Shared gene expression changes in humans and dogs with Cushing’s disease. Genes were grouped by overexpression (> 2-fold compared to normal) and underexpression (< 2-fold compared to normal) of normalized RNA-Seq FPKM levels of human (red) and dog (blue) specimens. 517 overexpressed and 1670 underexpressed human genes, and 127 overexpressed and 953 underexpressed dog genes were identified. Overlap of the 2 datasets demonstrated 14 overexpressed and 239 underexpressed genes between dog and man. The 14 commonly overexpressed genes were: AVPR1B, BIRC5, CEP55, FAM131B, FZD9, GLDC, MAMLD1, MNX1, POMC, PTGER4, RASEF, TBX19, TK1, and VIPR2