Fig. 1
From: The genomic profiling and MAMLD1 expression in human and canines with Cushing’s disease
Copy number variation of somatic mutations in corticotroph pituitary adenomas (PA) causing Cushing’s disease. Whole Exome Sequencing of 6 human PA specimens. Copy number gains (blue) and losses (red) are shown as a GISTIC profile (top) and for individual specimens. Prominent regions of focal gain (chr8:11,927,388-11,978,980_hg19) and loss (chr11:55,030,835-55,829,319_hg19) highlighted in the GISTIC profile represent regions of benign copy number variation. Focal gains or losses in 6 human PA specimens were not identified. Gain of whole chromosomes 5, 7, 8, 9, 12, 13 and 14 and loss of chromosome 19 were recurrent copy number abnormalities