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Table 3 Association between metabolic factors and multiple thyroid nodules analyzed by univariable binary logistic regression(vs. single thyroid nodules, N = 41,547 )

From: Prevalence and associated metabolic factors for thyroid nodules: a cross-sectional study in Southwest of China with more than 120 thousand populations

   

Total

   

Male

   

Female

 
 

STNs(N,%)

MTNs(N,%)

OR(95% CI)

Pvalue

STNs(N,%)

MTNs(N,%)

OR(95% CI)

P value

STNs(N,%)

MTNs(N,%)

OR(95% CI)

P value

BMI(Kg/m2)

  ≤ 18.4

679(51.4)

642(48.6)

0.96(0.86–1.07)

0.43

163(51.1)

156(48.9)

1.15(0.92–1.44)

0.21

516(51.5)

486(48.5)

0.84(0.73–0.95)

< 0.01

18.5–23.9

9854(50.3)

9749(49.7)

1.0(ref)

1.00

4555(54.7)

3778(45.3)

1.0(ref)

1.00

5299(47.0)

5971(53.0)

1.0(ref)

1.00

24.0-27.9

6497(48.4)

6921(51.6)

1.08(1.03–1.13)

< 0.01

4873(52.6)

4397(47.4)

1.09(1.03–1.15)

< 0.01

1624(39.2)

2524(60.8)

1.38(1.28–1.48)

< 0.01

≥ 28.0

1626(49.1)

1687(50.9)

1.05(0.97–1.13)

0.21

1311(54.2)

1107(45.8)

1.02(0.93–1.12)

0.70

315(35.2)

580(64.8)

1.63(1.42–1.88)

< 0.01

Central obesity(cm)

No

9826(51.3)

9340(48.7)

1.0(ref)

1.00

4278(55.8)

3392(44.2)

1.0(ref)

1.00

5548 (48.3)

5948(51.7)

1.0(ref)

1.00

Yes

8813(47.8)

5390(52.2)

1.15(1.11–1.20)

< 0.01

6622(52.3)

6039(47.7)

1.15(1.09–1.22)

< 0.01

2191(37.8)

3603(62.2)

1.53(1.44–1.64)

< 0.01

Hypertension

No

14,096(52.3)

12,858(47.7)

1.0(ref)

1.00

7591(56.6)

5815(43.4)

1.0(ref)

1.00

6505(48.0)

7043(52.0)

1.0(ref)

1.00

Yes

4626(42.7)

6203(57.3)

1.47(1.41–1.54)

< 0.01

3339(47.8)

3646(52.2)

1.43(1.35–1.51)

< 0.01

1287(33.5)

2557(66.5)

1.84(1.70–1.98)

< 0.01

Glucose status

Normal

17,704(51.0)

16,996(49.0)

1.0(ref)

1.00

9614(55.5)

7714(44.5)

1.0(ref)

1.00

8090(46.6)

9289(53.4)

1.0(ref)

1.00

IFG

1049(45.1)

1275(54.9)

1.27(1.16–1.38)

< 0.01

799(50.2)

792(49.8)

1.24(1.11–1.37)

< 0.01

250(34.1)

483(65.9)

1.68(1.44–1.97)

< 0.01

DM

1392(40.4)

2054(59.6)

1.54(1.43–1.65)

< 0.01

1109(43.9)

1420(56.1)

1.60(1.47–1.74)

< 0.01

283(30.9)

634(69.1)

1.95(1.69–2.25)

< 0.01

TC(mmol/L)

≤ 5.2

12,825(51.0)

12,337(49.0)

1.0(ref)

1.00

7099(53.4)

6185(46.6)

1.0(ref)

1.00

5726(48.2)

6152(51.8)

1.0(ref)

1.00

> 5.2

7385(47.8)

8079(52.2)

1.14(1.09–1.18)

< 0.01

4452(54.1)

3781(45.9)

0.97(0.92–1.03)

0.36

2933(40.6)

4298(59.4)

1.36(1.29–1.45)

< 0.01

TG(mmol/L)

≤ 1.7

13,697(49.7)

13,889(50.3)

1.0(ref)

1.00

6488(52.7)

5819(47.3)

1.0(ref)

1.00

7209(47.2)

8070(52.8)

1.0(ref)

1.00

> 1.7

6513(49.9)

6527(50.1)

0.99(0.95–1.03)

0.58

5063(55.0)

4147(45.0)

0.91(0.87–0.96)

< 0.01

1450(37.9)

2380(62.1)

1.47(1.36–1.58)

< 0.01

HDL-C(mmol/L)

≥ 0.9

19,207(49.6)

19,547(50.4)

 

1.00

10,733(53.6)

9292(46.4)

 

1.00

8474(45.2)

10,255(54.8)

 

1.00

< 0.9

884(53.1)

780(46.9)

0.87(0.79–0.96)

< 0.01

777(54.5)

649(45.5)

0.96(0.87–1.07)

0.51

107(45.0)

131(55.0)

1.01(0.78–1.31)

0.93

LDL-C(mmol/L)

≤ 3.1

11,667(50.6)

11,410(49.4)

1.0(ref)

1.00

6008(52.8)

5372(47.2)

1.0(ref)

1.00

5659(48.4)

6038(51.6)

1.0(ref)

1.00

> 3.1

8424(48.6)

8917(51.4)

1.08(1.04–1.13)

< 0.01

5502(54.6)

4569(45.4)

0.93(0.88–0.98)

0.01

2922(40.2)

4348(59.8)

1.39(1.31–1.48)

< 0.01

HUA(µmol/L)

No

15,802(49.4)

16,176(50.6)

1.0(ref)

1.00

8059(53.1)

7106(46.9)

1.0(ref)

1.00

7743(46.1)

9070(53.9)

1.0(ref)

1.00

Yes

4415(51.1)

4217(48.9)

0.93(0.89–0.98)

< 0.01

3495(55.0)

2859(45.0)

0.93(0.87–0.98)

0.01

920(40.4)

1358(59.6)

1.26(1.15–1.38)

< 0.01

Fatty Liver

No

13,884(50.1)

13,812(49.9)

1.0(ref)

1.00

6696(53.4)

5837(46.6)

1.0(ref)

1.00

7188(47.4)

7975(52.6)

1.0(ref)

1.00

Yes

6101(49.0)

6341(51.0)

1.04(1.00-1.09)

0.04

4785(53.9)

4094(46.1)

0.98(0.93–1.04)

0.50

1316(36.9)

2247(63.1)

1.54(1.43–1.66)

< 0.01

  1. STNs single thyroid nodules; MTNs multiple thyroid nodules; BMI body mass index; TC total cholesterol; TG triglyceride; HDL-C high-density lipoprotein cholesterol; LDL-C low-density lipoprotein cholesterol; DM diabetes mellitus; IFG impaired fasting glucose; HUA hyperuricemia