Table 2 Association between metabolic factors and thyroid nodules analyzed by univariable binary logistic regression (N = 121,702 )

BMI(Kg/m²)

  ≤ 18.4

1321(26.0)

3751(74.0)

0.71(0.67–0.76)

< 0.01

319(21.7)

1152(78.3)

0.73(0.64–0.83)

< 0.01

1002(28.1)

2599(71.9)

0.60(0.56–0.65)

< 0.01

18.5–23.9

19,603(33.1)

39,659(66.9)

1.0(ref)

1.00

8333(27.5)

22,009(72.5)

1.0(ref)

1.00

11,270(39.0)

17,659(61.0)

1.0(ref)

1.00

24.0-27.9

13,418(36.5)

23,390(63.5)

1.16(1.13–1.19)

< 0.01

9270(32.2)

19,509(67.8)

1.25(1.21–1.30)

< 0.01

4148(51.7)

3881(48.3)

1.67(1.59–1.76)

< 0.01

≥ 28.0

3313(35.7)

5976(64.3)

1.12(1.07–1.17)

< 0.01

2418(31.7)

5207(68.3)

1.23(1.16–1.30)

< 0.01

895(53.8)

769(46.2)

1.82(1.65–2.01)

< 0.01

Central obesity

No

19,166(31.4)

41,810(68.6)

1.0(ref)

1.00

7670(25.8)

22,104(74.2)

1.0(ref)

1.00

11,496(36.8)

19,706(63.2)

1.0(ref)

1.00

Yes

18,455(37.4)

30,890(62.6)

1.30(1.27–1.34)

< 0.01

12,661(33.0)

25,727(67.0)

1.42(1.37–1.47)

< 0.01

5794(52.9)

5163(47.1)

1.92(1.84–2.01)

< 0.01

Hypertension

No

26,954(31.0)

60,094(69.0)

1.0(ref)

1.00

13,406(26.3)

37,593(73.7)

1.0(ref)

1.00

13,548(37.6)

22,501(62.4)

1.0(ref)

1.00

Yes

10,829(45.6)

12,933(54.4)

1.87(1.81–1.92)

< 0.01

6985(40.2)

10,392(59.8)

1.88(1.82–1.95)

< 0.01

3844(60.2)

2541(39.8)

2.51(2.38–2.65)

< 0.01

Glucose status

Normal

34,700(32.5)

71,915

1.0(ref)

1.00

17,328(27.8)

45,033(72.2)

1.0(ref)

1.00

17,372(39.3)

26,882(60.7)

1.0(ref)

1.00

IFG

2324(42.9)

3091(57.1)

1.56(1.47–1.65)

< 0.01

1591(38.5)

2539(61.5)

1.63(1.53–1.74)

< 0.01

733(57.0)

552(43.0)

2.05(1.84–2.30)

< 0.01

DM

3446(50.1)

3437(49.9)

2.08(1.98–2.18)

< 0.01

2529(46.3)

2937(53.7)

2.24(2.12–2.37)

< 0.01

917(64.7)

500(35.3)

2.84(2.54–3.17)

< 0.01

TC(mmol/L)

≤ 5.2

25,162(32.1)

53,194(67.9)

1.0(ref)

1.00

13,284(28.9)

32,705(71.7)

1.0(ref)

1.00

20,489(63.3)

11,878(36.7)

1.0(ref)

1.00

> 5.2

15,464(37.7)

25,606(62.3)

1.28(1.25–1.31)

< 0.01

8233(31.4)

18,008(68.6)

1.13(1.09–1.16)

0.01

7231(48.8)

7598(51.2)

1.64(1.58–1.71)

< 0.01

TG(mmol/L)

≤ 1.7

27,586(33.5)

54,778(66.5)

1.0(ref)

1.00

12,307(28.9)

30,276(71.1)

1.0(ref)

1.00

15,279(38.4)

24,502(61.6)

1.0(ref)

1.00

> 1.7

13,040(35.2)

24,022(64.8)

1.08(1.05–1.11)

< 0.01

9210(31.1)

20,437(68.9)

1.11(1.07–1.15)

< 0.01

3830(51.7)

3585(48.3)

1.71(1.63–1.80)

< 0.01

HDL-C(mmol/L)

≥ 0.9

38,754(34.1)

74,737(65.9)

1.00

20,025(29.7)

47,374(70.3)

1.00

18,729(40.6)

27,363(59.4)

1.00

< 0.9

1664(33.5)

3309(66.5)

0.97(0.91–1.03)

0.32

1426(31.9)

3049(68.1)

1.11(1.04–1.18)

< 0.01

238(47.8)

260(52.2)

1.34(1.12–1.60)

< 0.01

LDL-C(mmol/L)

≤ 3.1

23,077(32.6)

47,762(67.4)

1.0(ref)

1.00

11,380(29.1)

27,678(70.9)

1.0(ref)

1.00

11,697(36.8)

20,084(63.2)

1.0(ref)

1.00

> 3.1

17,341(36.4)

30,284(63.6)

1.19(1.16–1.21)

< 0.01

10,071(30.7)

22,745(69.3)

1.08(1.04–1.11)

< 0.01

7270(49.1)

7539(50.9)

1.66(1.59–1.72)

0.01

HUA(µmol/L)

No

31,978(34.9)

59,717(65.1)

1.0(ref)

1.00

15,165(30.7)

34,237(69.3)

1.0(ref)

1.00

25,480(60.2)

16,813(39.8)

1.0(ref)

1.00

Yes

8632(31.1)

19,139(68.9)

0.84(0.82–0.87)

< 0.01

6354(27.8)

16,512(72.2)

0.87(0.84–0.90)

< 0.01

2278(46.4)

2627(53.6)

1.31(1.24–1.39)

< 0.01

Fatty Liver

No

27,696(32.9)

56,402(67.1)

1.0(ref)

1.00

12,533(28.3)

31,706(71.7)

1.0(ref)

1.00

15,163(38.0)

24,696(62.0)

1.0(ref)

1.00

Yes

12,442(36.7)

21,534(63.3)

1.18(1.15–1.21)

< 0.01

8879(32.2)

18,662(67.8)

1.20(1.16–1.24)

< 0.01

3563(55.4)

2872(44.6)

2.02(1.92–2.13)

< 0.01