Table 4 Overall and subgroup meta-analysis of the association between SERPINE1 rs1799889 SNP and risk of diabetic CVD
Categories | n | 4G vs. 5G | 4G4G vs. 5G5G | 4G5G vs. 5G5G | 4G4G + 4G5G vs. 5G5G | 4G4G vs. 4G5G + 5G5G | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | I2 (%)/ Ph | OR (95% CI) | P0.00 | I2 (%)/ Ph0.00/0.00 | OR(95% CI) | P | I2 (%)/ Ph | OR(95% CI) | P | I2 (%)/ Ph | OR(95% CI) | P | I2 (%)/ Ph | ||
Overall | 7 | 1.16(0.89–1.50) | 0.28 | 72 %/0.001 | 1.23(0.77–1.96) | 0.38 | 64 %/0.01 | 1.05 (FEM)(0.83–1.33) | 0.68 | 0 %/0.49 | 1.12(0.81–1.55) | 0.51 | 45 %/0.09 | 1.20(0.84–1.70) | 0.32 | 66 %/0.01 |
Subgroup (by population) | ||||||||||||||||
European | 4 | 1.07(0.81–1.42) | 0.63 | 70 %/0.02 | 1.08(0.65–1.80) | 0.77 | 62 %/0.05 | 1.00 (FEM)(0.77–1.31) | 0.97 | 0 %/0.56 | 1.12 (FEM)(0.89–1.40) | 0.35 | 0 %/0.43 | 1.13(0.76–1.68) | 0.54 | 67 %/0.03 |
Asian | 3 | 1.37(0.69–2.73) | 0.37 | 82 %/0.001 | 1.64(0.52–5.23) | 0.40 | 76 %/0.02 | 1.24(0.66–2.33) | 0.50 | 32 %/0.23 | 1.41(0.63–3.13) | 0.40 | 63 %/0.07 | 1.45(0.57–3.65) | 0.43 | 77 %/0.01 |