Table 3 Overall and subgroup meta-analysis of the association between SERPINE1 rs1799889 SNP and risk of diabetic retinopathy
Categories | n | 4G vs. 5G | 4G4G vs. 5G5G | 4G5G vs. 5G5G | 4G4G + 4G5G vs. 5G5G | 4G4G vs. 5G5G + 5G4G | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | I2 (%)/ Ph | OR (95% CI) | P0.00 | I2 (%)/ Ph0.00/0.00 | OR(95% CI) | P | I2 (%)/ Ph | OR(95% CI) | P | I2 (%)/ Ph | OR(95% CI) | P | I2 (%)/ Ph | ||
Overall | 10 | 1.08(0.97–1.20) | 0.15 | 28 %/0.19 | 1.25(1.01–1.56) | 0.04 | 23 %/0.23 | 1.00 (REM)(0.76–1.32) | 0.97 | 44 %/0.06 | 1.03(0.87–1.23) | 0.71 | 13 %/0.32 | 1.20(1.01–1.43) | 0.04 | 23 %/0.23 |
Subgroup (by population) | ||||||||||||||||
European | 5 | 1.12(0.98–1.27) | 0.09 | 0 %/0.66 | 1.32(1.02–1.72) | 0.04 | 26 %/0.25 | 0.88(0.71–1.09) | 0.24 | 0 %/0.55 | 1.00(0.82–1.22) | 0.98 | 0 %/0.63 | 1.38(1.11–1.71) | 0.001 | 26 %/0.25 |
Asian | 4 | 0.90(0.73–1.11) | 0.34 | 22 %/0.28 | 0.94(0.60–1.45) | 0.77 | 0 %/0.56 | 0.95(0.63–1.45) | 0.83 | 5 %/0.37 | 0.94(0.63–1.39) | 0.75 | 6 %/0.36 | 0.93(0.68–1.26) | 0.63 | 0 %/0.56 |
Others | 1 | 1.61(1.04–2.48) | 0.03 |  N/A | 2.53(0.98–6.55) | 0.06 |  N/A | 3.18(1.47–6.86) | 0.003 |  N/A | 2.27(1.07–4.82) | 0.03 |  N/A | 1.17(0.54–2.53) | 0.70 |  N/A |