The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Table 2 Overall and subgroup meta-analysis of the association between SERPINE1 rs1799889 SNP and risk of diabetes

Categories	n	4G vs. 5G			4G4G vs. 5G5G			4G5G vs. 5G5G			4G4G + 4G5G vs. 5G5G			4G4G vs. 5G5G + 5G4G
Categories	n	OR (95% CI)	P	I²(%)/Ph	OR (95% CI)	P0.00	I²(%)/Ph0.00/0.00	OR(95% CI)	P	I²(%)/Ph	OR(95% CI)	P	I²(%)/Ph	OR(95% CI)	P	I²(%)/Ph
Overall	19	1.34 (REM)(1.14–1.57)	0.001	71 %/0.001	1.62 (REM)(1.23–2.14)	0.001	58 %/0.001	1.35 (REM)(1.08–1.69)	0.001	51 %/0.01	1.49 (REM)(1.18–1.88)	0.001	62 %/0.001	1.30 (REM)(1.06–1.59)	0.01	50 %/0.01
Subgroup (by population)
European	3	1.07(0.94–1.23)	0.31	0 %/0.76	1.15(0.88–1.50)	0.31	0 %/0.69	1.10(0.86–1.40)	0.45	7 %/0.34	1.12(0.89–1.40)	0.35	0 %/0.43	1.08(0.88–1.33)	0.46	0 %/0.78
Asian	15	1.45 (REM)(1.16–1.82)	0.001	74 %/0.001	1.88 (REM)(1.29–2.75)	0.001	62 %/0.01	1.47 (REM)(1.08-2.00)	0.01	56 %/0.01	1.64 (REM)(1.21–2.24)	0.001	63 %/0.001	1.46(1.09–1.96)	0.01	58 %/0.001
Others	1	1.13(0.85–1.51)	0.41	N/A	1.27(0.71–2.25)	0.42	N/A	1.20(0.74–1.95)	0.47	N/A	1.22(0.77–1.93)	0.39	N/A	1.13(0.70–1.83)	0.63	N/A

n: study numbers, OR: odds ratio, CI: confidence interval, bold values represent statistically significant findings, Ph: P heterogeneity (P < 0.1 was considered as a significant difference), REM: Random Effects Model

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