Skip to main content

Table 1 Characteristics and genotype frequencies for the SERPINE1 rs1799889 SNP in the included studies

From: The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Study

Year

Country

Ethnicity

Sample size Case/Control

Study type

Outcomes

Genotyping methods

5G allele frequency

HWE

Case/Control (%)

Mansfield et al

1995

UK

European

38

122

Hospital based

CAD & NIDDM

PCR

27.6

42.2

Y

Nagi et al

1997

USA

Mix

70

101

Population based

DR & NIDDM

PCR

48.6

60.3

Y

Broch et al

1998

Spain

European

82

95

Hospital based

DR & NIDDM

PCR

51.2

54.7

Y

Kimura et al

1998

Japan

Asian

208

177

Population based

NIDDM

PCR

41.3

40.1

Y

110

98

Population based

PDR & NIDDM

PCR

42.7

39.8

Y

110

98

Population based

DN & NIDDM

PCR

41.8

40.9

Y

De Cosmo et al

1999

Italy & UK

European

311

200

Population based

IDDM

PCR

48.6

49.0

Y

175

136

Population based

DN & IDDM

PCR

47.1

50.4

Y

Wong et a

2000

Hong Kong

Asian

84

57

Hospital based

DR & NIDDM

PCR

40.5

47.4

Y

95

46

Hospital based

DN & NIDDM

PCR

39.5

51.1

Y

Tarnow et al

2000

Denmark

European

197

191

Hospital based

DN & IDDM

PCR

46.2

46.1

Y

Ding et al

2001

China

Asian

112

169

Hospital based

NIDDM

PCR

56.3

67.2

Y

49

63

Hospital based

CHD & NIDDM

PCR

54.9

64.3

Y

Li et al

2001

China

Asian

143

85

Hospital based

NIDDM

PCR

41.3

44.7

Y

79

64

Hospital based

DN & NIDDM

PCR

39.2

43.8

Y

Petrovic et al

2003

Slovenia

European

154

194

Population based

MI & NIDDM

PCR

46.8

42.0

Y

Santos et al

2003

Brazil

European

99

111

Hospital based

DR & NIDDM

PCR

55.1

53.6

Y

Globocnik-P et al

2003

Slovenia

European

124

80

Hospital based

DR & NIDDM

PCR

45.2

43.8

Y

Lopes et al

2003

France

European

229

406

Population based

CHD & NIDDM

PCR

44.1

48.9

Y

Liu et al

2004

China

Asian

147

26

Hospital based

NIDDM

PCR

45.9

53.8

Y

56

91

Hospital based

DR & NIDDM

PCR

50.0

43.4

Y

77

70

Hospital based

DN & NIDDM

PCR

42.9

49.3

Y

Pan et al

2004

China

Asian

204

60

Hospital based

NIDDM

PCR

52.7

56.7

Y

Li et al

2004

China

Asian

54

54

Population based

NIDDM

PCR

42.6

46.3

Y

Murata et al

2004

Japan

Asian

188

92

Hospital based

DR & NIDDM

PCR

35.6

34.2

Y

Tang et al

2004

China

Asian

108

38

Hospital based

NIDDM

PCR

38.9

46.1

Y

59

49

 

DN & NIDDM

PCR

31.4

48.0

Y

Wang et al

2004

China

Asian

114

30

Hospital based

NIDDM

PCR

34.6

61.7

Y

76

38

Hospital based

DN & NIDDM

PCR

28.3

47.4

Y

Meigs et al

2006

USA

European

216

1953

Population based

DM

PCR

46.1

47.4

Y

Zietz et al

2006

Germany

European

192

312

Population based

DR & NIDDM

PCR

42.4

44.4

Y

189

320

Population based

CHD & NIDDM

PCR

45.8

42.7

Y

Martin et al

2007

Ireland

European

222

361

Hospital based

DN & IDDM

PCR

42.8

44.5

Y

Zheng et al

2007

China

Asian

247

87

Hospital based

NIDDM

PCR

44.3

46.0

Y

167

80

Hospital based

DN & NIDDM

PCR

40.7

51.9

Y

Saely et al

2008

Austria

European

148

524

Population based

NIDDM

PCR

43.9

47.6

Y

 Yan et al 1

2008

China

Asian

66

33

Hospital based

NIDDM

PCR

50.8

56.1

Y

 Yan et al 2

2008

China

Asian

217

58

Population based

NIDDM

PCR

53.9

79.3

Y

125

92

Population based

DN & NIDDM

PCR

42.4

69.6

Y

Ezzidi et al

2009

Tunisia

European

383

473

Hospital based

DR & NIDDM

PCR

58.1

63.0

Y

Prasad et al

2010

India

Mix

196

225

Hospital based

DN & NIDDM

PCR

48.0

50.9

Y

Xue et al

2010

China

Asian

120

50

Hospital based

NIDDM

PCR

41.7

70.0

Y

70

50

Hospital based

DN & NIDDM

PCR

20.7

71.0

Y

Liu et al

2011

China

Asian

63

39

Hospital based

NIDDM

PCR

39.7

57.7

Y

29

34

Hospital based

DN & NIDDM

PCR

44.8

35.3

Y

Tan et al

2011

China

Asian

30

50

Hospital based

CHD & NIDDM

PCR

35.0

48.0

Y

Al-Hamodi et al

2012

Malaysia

Asian

303

131

Population based

NIDDM

PCR

50.0

53.1

Y

Weng et al

2012

Taiwan

Asian

27

251

Hospital based

PTDM

PCR

53.7

40.0

Y

Xu et al

2016

China

Asian

107

101

Hospital based

NIDDM

PCR

37.9

47.0

Y

65

42

Hospital based

DN & NIDDM

PCR

37.7

38.1

Y

Li et al

2018

China

Asian

175

125

Hospital based

IS & NIDDM

PCR

42.6

36.8

Y

  1. CAD coronary artery disease, CHD coronary heart disease, MI myocardial infarction, IS ischemic stroke, IDDM insulin-dependent diabetes mellitus, NIDDM non-insulin-dependent diabetes mellitus, PTDM post-transplant diabetes mellitus, PCR polymerase chain reaction, HWE Hardy-Weinberg equilibrium, Y Yes