Table 1 Characteristics of included studies
From: Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies
Author, Year | Location | Sample size (F/M) | Age (year) | BMI (kg/m2) | Study design | Population health status | Vit D assay method | Season of sample collection | Quality assessment score |
|---|---|---|---|---|---|---|---|---|---|
Bouillon et al., 1980 (a) | Belgium | 69/24 | 42 | – | Case-control | Hypothyroid patients | RIA | – | Moderate |
Bouillon et al., 1980 (b) | Belgium | 77/27 | 39 | – | Case-control | GD | RIA | – | Moderate |
Camurdan et al., 2012 | Turkey | 126/26 | 12.05 | – | Case-control | HT | HPLC | – | Low |
Yasuda et al., 2012 | Japan | 72 F | 40.8 | 21.75 | Case-control | GD | Competitive protein binding assay | Winter, spring | Moderate |
Jyotsna et al., 2012 | India | 124/36 | 36.37 | 22.05 | Case-control | GD | RIA | All season | Moderate |
Chailurkit et al., 2012 | Thailand | 1292/1290 | 55 | 23.3 | Cross- sectional | AITD | HPLC | All season | High |
Bozkurt et. al., 2013 | Turkey | 369/ 171 | 42.5 | 28.4 | Case-control | HT | ELISA | Summer | Moderate |
Mackawy et al., 2013 | Saudi Arabia | 35/25 | 46.38 | – | Case-control | Hypothyroid patients | Spectrophotometry | Autumn, winter, spring | Moderate |
Aljohani et al., 2013 | Saudi Arabia | 85/9 | 35.8 | 30.05 | Case-control | Hypothyroid patients | ELISA | – | Moderate |
Fawzy et al., 2013 (a) | Egypt | 43/8 | 32.39 | – | Case-control | Subclinical hypothyroid | CLIA | All season | Low |
Fawzy et al., 2013 (b) | Egypt | 44/12 | 31.66 | – | Case-control | Hypothyroid patients | CLIA | All season | Low |
Ucar et al., 2014 | Turkey | 62/15 | 74.95 | – | Case-control | Subclinical hypothyroid | CLIA | – | Moderate |
Unal et al., 2014 (a) | Turkey | 378 F&M | 44.6 | – | Case-control | HT | CLIA | – | Low |
Unal et al., 2014 (b) | Turkey | 151 F&M | 44.6 | – | Case-control | GD | CLIA | – | Low |
Demir et al., 2014 | Turkey | 24/14 | 12.95 | – | Case-control | AITD | – | – | Moderate |
Zhang et al., 2014 | China | 84/56 | 32.34 | 20.57 | Case - control | GD | ELISA | Summer, autumn | Moderate |
Shin et al., 2014 | Korea | 267/37 | 49.9 | – | Cross sectional | AITD | RIA | All season | High |
Choi et al., 2014 | Korea | 2793/3892 | 54.1 | 24.2 | Cross-sectional | AITD | RIA | All season | Moderate |
Evliyaoglu et al., 2015 | Turkey | 117/52 | 12.08 | – | Case-control | HT | HPLC | Winter, spring, summer | Moderate |
Ma et al., 2015 (a) | China | 100/ 40 | 41.05 | 28.18 | Case-control | HT | ECLA | Autumn, winter, spring | Moderate |
Ma et al., 2015 (b) | China | 97/43 | 41.01 | 28.18 | Case-control | GD | ECLA | Autumn, winter, spring | Moderate |
Maciejewski et al., 2015 | Poland | 84/10 | 47.62 | – | Case-control | HT | ELISA | Spring | Moderate |
Toulis et al., 2015 (a) | Greece | 264 F&M | 67.6 | 31.6 | Case - control | AITD+T2DM | RIA | Winter, spring | Moderate |
Toulis et al., 2015 (b) | Greece | 234 F&M | 72.2 | 30.6 | Case - control | AITD+control group | RIA | Winter, spring | Moderate |
Muscogiuri et al., 2015 | Italy | 50 F | 26.8 | 28.1 | Cross-sectional | AITD+PCOS | CLIA | Spring, summer | High |
Metwalley et al., 2015 | Egypt | 88/24 | 14.32 | 18.8 | Case-control | AITD | HPLC | – | Moderate |
Zhou et al., 2015 | USA | 1076/930 | 37.8 | 26.68 | Cross-sectional | AITD | – | – | High |
Sonmezgoz et al., 2016 | Turkey | 76/68 | 11.12 | – | Case-control | HT | CLIA | Autumn | Moderate |
Kim, 2016 | Korea | 641/135 | 45.25 | 23.6 | Cross-sectional | AITD | ECLIA | All season | High |
Giovinazzo et al, 2016 | Italy | 175/25 | 41 | 26.5 | Case-control | HT | HPLC | Autumn, winter, spring | Moderate |
Nalbant et al., 2017 | Turkey | 453 F | 40.3 | – | Case-control | HT | ECLA | Spring, summer, autumn | Moderate |
Musa et al., 2017 | Saudi Arabia | 116 F | 35.7 | – | Case-control | Hypothyroid patients | Spectrophotometry | Autumn, winter, spring | Moderate |
Ke et al., 2017 (a) | China | 65/47 | 38.68 | 22.57 | Case-control | HT | ECLA | Autumn, winter | Moderate |
Ke et al., 2017 (b) | China | 61/41 | 38.13 | 22.42 | Case-control | GD | ECLA | Autumn, winter | Moderate |
Lawnicka et al., 2017 | Poland | 56/15 | 54.4 | – | Case-control | HT | CLIA | Winter, spring | Moderate |
Planck et al., 2017 | Sweden | 1167/1430 | 52.45 | – | Case-control | GD | – | All season | Moderate |
Mirhosseini et al., 2017 | Canada | 515 F&M | 48 | 27.6 | Case-control | Hypothyroid patients | HPLC | All season | Moderate |
Akdere G et al., 2018 | Turkey | 66/94 | 28.3 | – | Case-control | AITD+T1DM | ELISA | All season | Moderate |
Kmiec et al., 2018 | Poland | 194/30 | 42 | 25.9 | Cross-sectional | Hypothyroid patients | HPLC | Summer | High |
Komisarenko & Bobryk, 2018 (a) | Ukraine | 29/21 | 39.5 | 31.25 | Case- control | AITD+T1DM | ELISA | – | Moderate |
Komisarenko & Bobryk, 2018 (b) | Ukraine | 31/19 | 57.25 | 37.25 | Case- control | AITD+ T2DM | ELISA | – | Moderate |
Botelho et al., 2018 | Brazil | 143/15 | 46.8 | – | Case-control | HT | CLIA | Spring, summer | Low |