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Table 3 Correlations of the relative expressions of microRNA-29a and microRNA-122, serum sestrin 2, hsCRP, IL-6 and TNF-α levels with the studied anthropometric and metabolic parameters in G1, G2 and G3

From: Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study

  WC percentile BMI percentile HDL-c (mg/dl) LDL-c (mg/dl) TAG (mg/dl) Cholesterol
(mg/ml)
HbA1c
(%)
Glucose (mg/dl) Insulin (μg/ml) C-Peptide (ng/ml) HOMA-IR hsCRP (mg/dl) IL-6 (pg/ml) TNF-α (pg/ml)
G1; Healthy control group
(n = 68)
miR-29aR r 0.163 0.068 −0.002 0.204* 0.249** 0.238** 0.252** 0.287** 0.206* −0.132 0.002 0.024 0.051 0.035
miR-122R r 0.428** 0.515** −0.241** 0.105 −0.138 0.045 0.060 −0.023 0.207* 0.165 0.145 0.102 0.056 0.069
Sestrin2
(ng/ml)
r 0.054 0.055 0.186* 0.125 −0.079 0.082 0.017 −0.074 0.089 −0.014 0.039 −0.019 0.046 0.014
hsCRP (mg/dl) r 0.143 0.207* −0.256** −0.061 − 0.111 −0.045 − 0.124 −0.031 − 0.127 −0.117 0.095 1 0.185* 0.234**
IL-6 (pg/ml) r 0.128 0.227** −0.044 0.014 −0.087 − 0.008 −0.002 − 0.025 0.101 0.136 0.059   1 0.870**
TNF-α (pg/ml) r 0.070 0.170 0.047 −0.056 −0.050 −0.056 − 0.022 −0.003 0.125 0.129 0.087    1
G2; Obese group
(n = 45)
miR-29aR r 0.219* 0.418** −0.586** 0.169 −0.153 − 0.050 −0.099 0.790** −0.091 − 0.063 0.718** 0.294** 0.257** 0.443**
miR-122R r 0.375** 0.639** −0.329** −0.133 0.231* 0.270** 0.292** 0.387** −0.033 −0.003 0.356** 0.178* 0.201* 0.316**
Sestrin2 (ng/ml) r −0.613** −0.341** 0.297** 0.021 0.087 0.129 0.113 −0.619** 0.121 0.050 −0.542** −0.579** − 0.555** −0.674**
hsCRP (mg/dl) r 0.632** 0.309** −0.328** −0.118 − 0.048 0.226* − 0.044 0.403** − 0.062 −0.002 0.364** 1 0.475** 0.712**
IL-6 (pg/ml) r 0.401** 0.360** −0.277** − 0.022 −0.069 − 0.120 −0.260* 0.468** −0.146 − 0.042 0.398**   1 0.542**
TNF-α (pg/ml) r 0.388** 0.399** −0.293** −0.077 − 0.092 −0.182 − 0.118 0.515** − 0.184 −0.173 0.428**    1
G3; Obese with type 2 diabetes
(n = 34)
miR-29aR r 0.405** 0.474** −0.309** 0.635** 0.554** 0.734** 0.574** 0.632** 0.265* 0.466** 0.630** 0.424** 0.464** 0.512**
miR-122R r 0.631** 0.485** −0.346** 0.602** 0.688** 0.607** 0.647** 0.556** 0.591** 0.558** 0.719** 0.488** 0.394** 0.560**
Sestrin2 (ng/ml) r −0.740** −0.462** 0.053 −0.515** −0.311** − 0.533** −0.797** − 0.603** −0.217* − 0.676** −0.593** − 0.541** −0.600** − 0.558**
hsCRP (mg/dl) r 0.757** 0.622** −0.291* 0.667** 0.516** 0.625** 0.690** 0.740** 0.238* 0.333** 0.711** 1 0.643** 0.773**
IL-6 (pg/ml) r 0.691** 0.425** −0.234* 0.524** 0.463** 0.510** 0.724** 0.665** 0.338** 0.413** 0.583**   1 0.529**
TNF-α (pg/ml) r 0.739** 0.581** −0.458** 0.656** 0.609** 0.570** 0.711** 0.701** 0.351** 0.673** 0.610**    1
  1. The values presented in the table are for the correlation coefficient
  2. non-significant correlation
  3. *correlation is significant at 0.05
  4. **correlation is significant at 0.01
  5. WC: waist circumference, BMI: body mass index, HDL-c: high density lipoprotein cholesterol, LDL-c: low density lipoprotein cholesterol, TAG: triacylglycerol, HbA1c: glycosylated hemoglobin, HOMA-IR: Homeostatic model Assessment-Insulin resistance, miR-29a R: microRNA-29a relative expression, miR-122 R: microRNA-122 relative expression, hsCRP: high-sensitivity C-reactive protein, IL-6: interleukin 6, TNF-α: tumor necrosis factor alpha