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Table 3 Correlations of the relative expressions of microRNA-29a and microRNA-122, serum sestrin 2, hsCRP, IL-6 and TNF-α levels with the studied anthropometric and metabolic parameters in G1, G2 and G3

From: Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study

 

WC percentile

BMI percentile

HDL-c (mg/dl)

LDL-c (mg/dl)

TAG (mg/dl)

Cholesterol

(mg/ml)

HbA1c

(%)

Glucose (mg/dl)

Insulin (μg/ml)

C-Peptide (ng/ml)

HOMA-IR

hsCRP (mg/dl)

IL-6 (pg/ml)

TNF-α (pg/ml)

G1; Healthy control group

(n = 68)

miR-29aR

r

0.163♣

0.068♣

−0.002♣

0.204*

0.249**

0.238**

0.252**

0.287**

0.206*

−0.132♣

0.002♣

0.024♣

0.051♣

0.035♣

miR-122R

r

0.428**

0.515**

−0.241**

0.105♣

−0.138♣

0.045♣

0.060♣

−0.023♣

0.207*

0.165♣

0.145♣

0.102♣

0.056♣

0.069♣

Sestrin2

(ng/ml)

r

0.054♣

0.055♣

0.186*

0.125♣

−0.079♣

0.082♣

0.017♣

−0.074♣

0.089♣

−0.014♣

0.039♣

−0.019♣

0.046♣

0.014♣

hsCRP (mg/dl)

r

0.143♣

0.207*

−0.256**

−0.061♣

− 0.111♣

−0.045♣

− 0.124♣

−0.031♣

− 0.127♣

−0.117♣

0.095♣

1

0.185*

0.234**

IL-6 (pg/ml)

r

0.128♣

0.227**

−0.044♣

0.014♣

−0.087♣

− 0.008♣

−0.002♣

− 0.025♣

0.101♣

0.136♣

0.059♣

 

1

0.870**

TNF-α (pg/ml)

r

0.070♣

0.170♣

0.047♣

−0.056♣

−0.050♣

−0.056♣

− 0.022♣

−0.003♣

0.125♣

0.129♣

0.087♣

  

1

G2; Obese group

(n = 45)

miR-29aR

r

0.219*

0.418**

−0.586**

0.169♣

−0.153♣

− 0.050♣

−0.099♣

0.790**

−0.091♣

− 0.063♣

0.718**

0.294**

0.257**

0.443**

miR-122R

r

0.375**

0.639**

−0.329**

−0.133♣

0.231*

0.270**

0.292**

0.387**

−0.033♣

−0.003♣

0.356**

0.178*

0.201*

0.316**

Sestrin2 (ng/ml)

r

−0.613**

−0.341**

0.297**

0.021♣

0.087♣

0.129♣

0.113♣

−0.619**

0.121♣

0.050♣

−0.542**

−0.579**

− 0.555**

−0.674**

hsCRP (mg/dl)

r

0.632**

0.309**

−0.328**

−0.118♣

− 0.048♣

0.226*

− 0.044♣

0.403**

− 0.062♣

−0.002♣

0.364**

1

0.475**

0.712**

IL-6 (pg/ml)

r

0.401**

0.360**

−0.277**

− 0.022♣

−0.069♣

− 0.120♣

−0.260*

0.468**

−0.146♣

− 0.042♣

0.398**

 

1

0.542**

TNF-α (pg/ml)

r

0.388**

0.399**

−0.293**

−0.077♣

− 0.092♣

−0.182♣

− 0.118♣

0.515**

− 0.184♣

−0.173♣

0.428**

  

1

G3; Obese with type 2 diabetes

(n = 34)

miR-29aR

r

0.405**

0.474**

−0.309**

0.635**

0.554**

0.734**

0.574**

0.632**

0.265*

0.466**

0.630**

0.424**

0.464**

0.512**

miR-122R

r

0.631**

0.485**

−0.346**

0.602**

0.688**

0.607**

0.647**

0.556**

0.591**

0.558**

0.719**

0.488**

0.394**

0.560**

Sestrin2 (ng/ml)

r

−0.740**

−0.462**

0.053♣

−0.515**

−0.311**

− 0.533**

−0.797**

− 0.603**

−0.217*

− 0.676**

−0.593**

− 0.541**

−0.600**

− 0.558**

hsCRP (mg/dl)

r

0.757**

0.622**

−0.291*

0.667**

0.516**

0.625**

0.690**

0.740**

0.238*

0.333**

0.711**

1

0.643**

0.773**

IL-6 (pg/ml)

r

0.691**

0.425**

−0.234*

0.524**

0.463**

0.510**

0.724**

0.665**

0.338**

0.413**

0.583**

 

1

0.529**

TNF-α (pg/ml)

r

0.739**

0.581**

−0.458**

0.656**

0.609**

0.570**

0.711**

0.701**

0.351**

0.673**

0.610**

  

1

  1. The values presented in the table are for the correlation coefficient
  2. ♣ non-significant correlation
  3. *correlation is significant at 0.05
  4. **correlation is significant at 0.01
  5. WC: waist circumference, BMI: body mass index, HDL-c: high density lipoprotein cholesterol, LDL-c: low density lipoprotein cholesterol, TAG: triacylglycerol, HbA1c: glycosylated hemoglobin, HOMA-IR: Homeostatic model Assessment-Insulin resistance, miR-29a R: microRNA-29a relative expression, miR-122 R: microRNA-122 relative expression, hsCRP: high-sensitivity C-reactive protein, IL-6: interleukin 6, TNF-α: tumor necrosis factor alpha
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BMC Endocrine Disorders

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