Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study

Table 2 Correlations of the relative expressions of microRNA-29a and microRNA-122, serum sestrin 2, hsCRP, IL-6 and TNF-α levels with the studied anthropometric and metabolic parameters in whole study sample

	WC percentile	BMI percentile	HDL-c (mg/dl)	LDL-c (mg/dl)	TAG (mg/dl)	Cholesterol (mg/ml)	HbA1c (%)	Glucose (mg/dl)	Insulin (μg/ml)	C-Peptide (ng/ml)	HOMA-IR	hsCRP (mg/dl)	IL-6 (pg/ml)	TNF-α (pg/ml)
miR-29aR	0.478^**	0.458^**	−0.315^**	0.460^**	0.517^**	0.365^**	0.570^**	0.654^**	0.356^**	0.254^**	0.651^**	0.497^**	0.267^**	0.355^**
miR-122R	0.610^**	0.619^**	−0.457^**	0.277^**	0.384^**	0.201^♣	0.468^**	0.412^**	0.513^**	0.293^**	0.631^**	0.502^**	0.427^**	0.453^**
Sestrin2 (ng/ml)	−0.495^**	−0.844^**	0.308^*	−0.215^*	−0.273^**	− 0.077^♣	−0.428^**	− 0.321^**	−0.331^**	− 0.227^**	−0.558^**	− 0.577^**	−0.504^**	− 0.541^**
hsCRP (mg/dl)	0.874^**	0.815^**	−0.455^**	0.231^**	0.402^**	0.277^**	0.672^**	0.578^**	0.342^**	0.366^**	0.605^**	1	0.521^**	0.664^**
IL-6 (pg/ml)	0.440^**	0.411^**	−0.364^**	0.271^**	0.362^**	0.271^**	0.456^**	0.481^**	0.358^**	0.319^**	0.748^**		1	0.626^**
TNF-α (pg/ml)	0.529^**	0.510^**	−0.456^**	0.287^**	0.508^**	0.289^**	0.613^**	0.506^**	0.469^**	0.428^**	0.679^**			1

The values presented in the table are for the correlation coefficient
^♣ non-significant correlation
^*correlation is significant at 0.05
^**correlation is significant at 0.01
WC: waist circumference, BMI: body mass index, HDL-c: high density lipoprotein cholesterol, LDL-c: low density lipoprotein cholesterol, TAG: triacylglycerol, HbA1c: glycosylated hemoglobin, HOMA-IR: Homeostatic model Assessment-Insulin resistance, miR-29a R: microRNA-29a relative expression, miR-122 R: microRNA-122 relative expression, hsCRP: high-sensitivity C-reactive protein, IL-6: interleukin 6, TNF-α: tumor necrosis factor alpha

ISSN: 1472-6823