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Table 1 Comparison of different variables among G1, G2 and G3

From: Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study

 

Healthy control group

(G1; n = 136)

Obese group

(G2; n = 90)

Obese with type 2 diabetes group

(G3; n = 72)

Gender

n (%)

Male

88 (64.7%)

62 (68.9%)

45 (62.5%) a, ¶

Female

48 (35.3%)

28 (31.1%)

27 (37.5%) a, ¶

Age (years)

12.1 ± 1.3

12.2 ± 1.4

12.2 ± 1.2 ¶

WC percentile

72.3 ± 7.2

95.9 ± 2.9

96.1 ± 2.9 *

BMI percentile

79.1 ± 6.8

96.8 ± 1.5

96.7 ± 1.4 *

HDL-c (mg/dl)

41.2 ± 2.9

35.7 ± 8.5

34.0 ± 9.5 *

LDL-c (mg/dl)

120.4 ± 21.4

126.1 ± 25.6

132.4 ± 17.0

TAG (mg/dl)

107.8 ± 19.6

112.7 ± 21.3

142.4 ± 37.1

Cholesterol (mg/dl)

183.2 ± 21.6

184.4 ± 26.6

194.9 ± 21.1

Glucose (mg/dl)

81.7 ± 12.7

96.8 ± 20.6

106.5 ± 25.7 #

HbA1c (%)

4.4 ± 0.7

6.0 ± 1.8

7.9 ± 1.9 #

Insulin (μg/ml)

7.6 ± 1.7

10.2 ± 0.7

10.6 ± 1.2*

C-Peptide (ng/ml)

2.8 ± 0.4

3.0 ± 0.3

3.1 ± 0.3 ♣

HOMA-IR

1.5 ± 0.4

2.4 ± 0.5

2.8 ± 0.6 #

miR-29a R

1.5 ± 0.3

1.9 ± 0.2

2.3 ± 0.3 #

miR-122 R

1.6 ± 0.3

1.9 ± 0.6

2.6 ± 0.9 #

Sestrin2 (ng/mL)

5.8 ± 1.8

4.1 ± 2.6

2.9 ± 1.4 #

hsCRP (mg/dl)

0.8 ± 0.1

1.3 ± 0.1

1.4 ± 0.2 #

IL-6 (pg/ml)

1.8 ± 0.4

2.2 ± 0.8

2.7 ± 1.1 #

TNF-α (pg/ml)

1.1 ± 0.2

1.3 ± 0.1

1.6 ± 0.6 #

  1. Unless otherwise indicated, the data is presented as mean ± Standard deviation
  2. WC: waist circumference, BMI: body mass index, HDL-c: high density lipoprotein cholesterol, LDL-c: low density lipoprotein cholesterol, TAG: triacylglycerol, HbA1c: glycosylated hemoglobin, HOMA-IR: Homeostatic model Assessment-Insulin resistance, miR-29a R: microRNA-29a relative expression, miR-122 R: microRNA-122 relative expression, hsCRP: high-sensitivity C-reactive protein, IL-6: interleukin 6, TNF-α: tumor necrosis factor alpha
  3. aChi-square
  4. ¶ the p-values of G1 Vs. G2 Vs. G3, G1 Vs. G2, G1 Vs. G3 and G2 Vs. G3 were non-significant
  5. * the p-values of G1 Vs. G2 Vs. G3, G1 Vs. G2, and G1 Vs. G3 were > 0.001 while G2 Vs. G3 were non-significant
  6. # the p-values of G1 Vs. G2 Vs. G3, G1 Vs. G2, G1 Vs. G3 and G2 Vs. G3 were > 0.001
  7. ♣ the p-values of G1 Vs. G2 Vs. G3, G1 Vs. G2, G1 Vs. G3 and G2 Vs. G3 were (0.01, 0.02, 0.009 and 0.44, respectively)
  8. The p-values of G1 Vs. G2 Vs. G3 for LDL-c (0.06), TAG (> 0.001) and Cholesterol (non-significant