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Table 3 Genes with good or highly suggestive evidence of specific relevance to obesity, diabetes and metabolic syndrome

From: Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study

Gene

Disease Association or trait reported in humans

Putative mechanism

C-Type Lectin Domain Containing 10 A (CLEC10A)

Obesity, T2D

Adaptive and immune responses

Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1)

T2D

Regulator of beta cell function and of immune function

Neuronal Growth Regulator 1 (NEGR1)

BMI, wait circumference, T2D

Cell adhesion

NAD(P)H Quinone Dehydrogenase 1 (NQO1)

Obesity, T2D. liver dysfunction

Anti-oxidant defences

Inhibin Subunit Beta E (INHBE )

Metabolic Syndrome, coronary heart disease

Cell proliferation, apoptosis, immune responses and hepatokine and hormone secretion

Glutamate receptor interacting protein 1 (GRIP1)

Metabolic syndrome (hepatic steatosis, hyperglycaemia and increased insulin resistance)

Macrophage and neuronal function and increased inflammation

Clusterin (CLU)

Glucose intolerance

Increased insulin resistance

Growth Factor Binding Protein 3 (IGFBP3)

Obesity, T2D, cerebrovascular disease

IGF binding protein affects vitamin D metabolism

Potassium Voltage-Gated Channel Subfamily Q Member 5 (KCNQ5)

Body mass index

Potassium channel

Cytotoxic And Regulatory T-Cell Molecule (CRTAM)

Body mass index and systolic hypertension

Innate immune system and determinant of insulin secretion

Spectrin (SPTA1)

HbA1c and T2D

Stability and structure of the cell membrane contributing to cell adhesion, cell spreading, and the cell cycle

  1. Legend: T2D type 2 diabetes, HbA1c glycosylated haemoglobin