Table 1 Definitions of Percent Specific Binding Used in Radioimmunoprecipitation Assays
Assay | Percent specific binding definition | |
|---|---|---|
MYL-1501D | Total ADA | %B/T (no inhibitor) − %B/T (excess MYL-1501D) |
Insulin cross-reactive ADA | %B/T (no inhibitor) − %B/T (excess insulin) | |
Drug-specific ADA | %B/T (excess IGlar) − %B/T (excess MYL-1501D) | |
IGlar | Total ADA | %B/T (no inhibitor) − %B/T (excess reference insulin glargine) |
Insulin cross-reactive ADA | %B/T (no inhibitor) − %B/T (excess insulin) | |
Drug-specific ADA | %B/T (excess MYL-1501D) − %B/T (excess IGlar) | |