Table 4 Glucose metabolism parameters in women with prior menstrual disorders and controls before and after HRT
Variable | Perimenopausal | Postmenopausal | ||||
|---|---|---|---|---|---|---|
Normal menstruation (N = 410) | Menstrual disorders (N = 46) | P valuea | Normal menstruation (N = 120) | Menstrual disorders (N = 19) | P valuea | |
FPGÂ (mmol/L) | ||||||
 Before HRT | 5.23 (4.93, 5.53) | 5.14 (4.85, 5.49) | 0.25 | 5.33 (5.00, 5.63) | 5.50 (4.84, 5.97) | 0.40 |
 After HRT | 5.13 (4.87, 5.41) | 5.02 (4.81, 5.58) | 0.49 | 5.12 (4.93, 5.41) | 5.18 (4.85, 5.32) | 0.75 |
P valueb | 0.000 | 0.64 | Â | 0.000 | 0.002 | Â |
 Δ FPG†(mmol/L) | −0.10(− 0.42, 0.18) | 0.01(− 0.37,0.19) | 0.36 | − 0.17(− 0.44, 0.07) | −0.37(− 0.67, 0.06) | 0.11 |
FIN (mU/L) | ||||||
 Before HRT | 5.60 (4.30, 7.34) | 5.82 (4.73,7.63) | 0.26 | 5.83 (4.10, 8.16) | 6.25 (3.40, 7.73) | 0.93 |
 After HRT | 5.03 (3.79, 6.37) | 5.10 (4.08, 7.03) | 0.36 | 4.75 (3.50, 6.20) | 4.50 (3.10, 6.10) | 0.97 |
P valueb | 0.000 | 0.006 | Â | 0.000 | 0.12 | Â |
 Δ FIN†(mU/L) | −0.70(−2.34, 0.60) | −0.60(−1.91, 0.00) | 0.86 | −1.07(−2.51, 0.36) | − 0.20(−3.10, 1.10) | 0.80 |
HOMA-IR | ||||||
 Before HRT | 1.29 (0.98, 1.74) | 1.37 (1.05,1.83) | 0.38 | 1.37 (0.96, 1.96) | 1.62 (0.84, 1.88) | 0.81 |
 After HRT | 1.15 (0.85, 1.51) | 1.20 (0.88, 1.61) | 0.43 | 1.05 (0.76, 1.47) | 1.06 (0.70, 1.47) | 1.00 |
P valueb | 0.000 | 0.008 | Â | 0.000 | 0.05 | Â |
 Δ HOMA-IR†| −0.17(−0.59, 0.13) | −0.18(− 0.49, 0.09) | 0.89 | − 0.28(− 0.67, 0.03) | −0.19(− 0.92, 0.15) | 0.88 |