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Table 3 Lipid metabolism parameters in women with prior menstrual disorders and controls before and after HRT

From: Effects of hormone replacement therapy on glucose and lipid metabolism in peri- and postmenopausal women with a history of menstrual disorders

Variable

Perimenopausal

Postmenopausal

Normal menstruation

(N = 410)

Menstrual disorders

(N = 46)

P valuea

Normal menstruation

(N = 120)

Menstrual disorders

(N = 19)

P valuea

TG (mmol/L)

 Before HRT

0.99 (0.76, 1.38)

0.95 (0.76, 1.33)

0.42

1.17 (0.83, 1.65)

1.19 (0.88, 1.51)

0.82

 After HRT

1.08 (0.80, 1.46)

0.89 (0.66, 1.70)

0.39

1.17 (0.86, 1.57)

1.06 (0.88, 1.76)

0.66

P valueb

0.001

0.08

 

0.44

0.93

 

 Δ TG† (mmol/L)

0.05(−0.16, 0.33)

0.10(− 0.18, 0.50)

0.43

− 0.04(− 0.31, 0.25)

0.06(− 0.45, 0.41)

0.82

TC (mmol/L)

 Before HRT

5.08 (4.57, 5.64)

5.00 (4.47 5.60)

0.83

5.43 (4.71, 5.94)

5.07 (4.22, 5.43)

0.05

 After HRT

4.91 (4.48, 5.53)

4.75 (4.35, 5.53)

0.47

5.24 (4.59, 5.74)

5.00 (4.56, 5.30)

0.17

P valueb

0.000

0.06

 

0.001

0.59

 

 Δ TC† (mmol/L)

−0.11(−0.50, 0.22)

−0.17(− 0.56, 0.22)

0.51

− 0.27(− 0.58, 0.18)

−0.05(− 0.37, 0.42)

0.19

HDL-C (mmol/L)

 Before HRT

1.54 (1.34, 1.79)

1.62 (1.35, 1.82)

0.38

1.47 (1.26, 1.77)

1.29 (1.19, 1.70)

0.28

 After HRT

1.64 (1.39, 1.89)

1.60 (1.33, 1.85)

0.57

1.51 (1.33, 1.78)

1.36 (1.18, 1.69)

0.11

P valueb

0.000

0.92

 

0.06

0.79

 

 Δ HDL-C†(mmol/L)

0.06(−0.07, 0.24)

−0.02(− 0.18, 0.20)

0.12

0.05(− 0.12, 0.21)

−0.01(− 0.11, 0.08)

0.30

LDL-C (mmol/L)

 Before HRT

2.76 (2.37, 3.25)

2.63 (2.20, 3.16)

0.27

3.07 ± 0.77

2.91 ± 0.68

0.42

 After HRT

2.67 (2.21, 3.09)

2.64 (2.14, 3.12)

0.72

2.87 ± 0.74

2.79 ± 0.69

0.68

P valueb

0.000

0.57

 

0.004

0.28

 

 Δ LDL-C†(mmol/L)

−0.11(−0.41, 0.22)

−0.19(− 0.45, 0.17)

0.98

− 0.14(− 0.63, 0.24)

− 0.18(− 0.32, 0.25)

0.82

  1. Data are expressed as medians (25th percentile, 75th percentiles) or mean ± standard deviation as appropriate. P < 0.05 was considered significant. †Value of the difference between the baseline and follow-up serum lipid parameters (TG, TC, HDL-C, and LDL-C). aP values are for between-group differences by Mann-Whitney U test or independent samples t-test. bP values are for within-group differences by Wilcoxon signed-rank test or paired-samples t test
  2. Others: HDL-C high-density lipoprotein cholesterol, HRT hormone replacement therapy, LDL-C Low-density lipoprotein cholesterol, TC total cholesterol, TG triglyceride
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