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Fig. 6 | BMC Endocrine Disorders

Fig. 6

From: LncRNA HCP5 knockdown inhibits high glucose-induced excessive proliferation, fibrosis and inflammation of human glomerular mesangial cells by regulating the miR-93-5p/HMGA2 axis

Fig. 6

MiR-93-5p bound to HMGA2 3’UTR. A The binding site between HMGA2 and miR-93-5p. The relationship between miR-93-5p and HMGA2 was confirmed using (B) dual-luciferase reporter assay and (C) pull-down assay. D The expression of HMGA2 protein in HGMCs transfected with miR-93-5p or miR-NC was detected by western blot. E The expression of HMGA2 protein in HG- and NG-treated HGMCs was detected by western blot. F The expression of HMGA2 in serum samples from DN patients and normal subjects was measured by QPCR. G and H The correlation between HMGA2 expression and miR-93-5p expression or HCP5 expression in DN serum samples was determined by Pearson correlation coefficient. ***P < 0.001

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BMC Endocrine Disorders

ISSN: 1472-6823

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