Post-operative volumes following endoscopic surgery for non-functioning pituitary macroadenomas are predictive of further intervention, but not endocrine outcomes

Table 4 Comparison of parameters between the first and second half of the study period

Characteristic	Study period		p-value
Characteristic	2009–2013	2014–2018	p-value
Patients (n = 159)	48	111
Preoperative tumour volume (median, cm³)	5.51 (IQR: 2.84–9.56)	5.51 (IQR: 3.56–9.27)	0.75
Postoperative residual tumour volume (median, cm³)	1.28 (IQR: 0.61–2.19)	0.77 (IQR: 0.39–1.72)	0.01*
EOR (median, %)	78.3 (IQR: 63.5–84.2)	86.4 (IQR: 70.4–93.8)	0.005**
Endocrine Outcomes (n = 101)^a
• Preserved function	23/34 (67.6%)	37/67 (56.7%)	0.29
• New hormone deficit(s)	8/34 (23.5%)	17/67 (25.4%)	0.99
• Axis recovery	3/34 (8.8%)	13/67 (19.4%)	0.25

^aComplete endocrine data pre- and post-TSS was available in 101 patients (34 of whom were in the first half, 2009–2013 and 67 in the second half, 2014–2018)

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